Recent advances in tumor biology have revealed that a detailed analysis of the complex
interactions of tumor cells with their adjacent microenvironment (tumor stroma) is mandatory …

This article focuses on the role of Rho family GTPases, particularly Rac1 and Rac1b in TGF‐
β‐induced epithelial‐mesenchymal transition (EMT) and EMT‐associated responses such …

Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound
hepatocellular dysfunction for which targeted treatments are urgently needed. Identification …

The discovery that endoplasmic reticulum (ER) luminal chaperones such as GRP78/BiP can
escape to the cell surface upon ER stress where they regulate cell signaling, proliferation …

Cancer metastasis requires the transient activation of cellular programs enabling
dissemination and seeding in distant organs. Genetic, transcriptional and translational …

Transforming growth factor (TGF)-β induces epithelial-mesenchymal transition (EMT) in
pancreatic adenocarcinoma. In this study, we investigated how NADPH oxidase (Nox) 4 …

Src plays a crucial role in many signaling pathways and contributes to a variety of cancers.
Therefore, Src has long been considered an attractive drug target in oncology. However, the …

Peritoneal response to various kinds of injury involves loss of peritoneal mesothelial cells
(PMC), danger signalling, epithelial-mesenchymal transition and mesothelial-mesenchymal …

This article focusses on the role of TGF-β and its signaling crosstalk with the RHO family
GTPases RAC1 and RAC1b in the progression of breast and pancreatic carcinoma. The …

Loss of ERα in breast cancer correlates with poor prognosis, increased recurrence rates,
and higher incidence of metastasis. Epigenetic silencing of E-cadherin (loss of which is …