The ENGases: versatile biocatalysts for the production of homogeneous N-linked glycopeptides and glycoproteins

AJ Fairbanks - Chemical Society Reviews, 2017 - pubs.rsc.org
The endo-β-N-acetylglucosaminidases (ENGases) are an enzyme class (EC 3.2. 1.96)
produced by a range of organisms, ranging from bacteria, through fungi, to higher order …

Bacterial chitinases and chitin-binding proteins as virulence factors

RF Frederiksen, DK Paspaliari, T Larsen… - …, 2013 - microbiologyresearch.org
Bacterial chitinases (EC 3.2. 1.14) and chitin-binding proteins (CBPs) play a fundamental
role in the degradation of the ubiquitous biopolymer chitin, and the degradation products …

Complex N-glycan breakdown by gut Bacteroides involves an extensive enzymatic apparatus encoded by multiple co-regulated genetic loci

J Briliūtė, PA Urbanowicz, AS Luis, A Baslé… - Nature …, 2019 - nature.com
Glycans are the major carbon sources available to the human colonic microbiota. Numerous
N-glycosylated proteins are found in the human gut, from both dietary and host sources …

Oligosaccharides released from milk glycoproteins are selective growth substrates for infant-associated bifidobacteria

S Karav, A Le Parc… - Applied and …, 2016 - Am Soc Microbiol
Milk, in addition to nourishing the neonate, provides a range of complex glycans whose
construction ensures a specific enrichment of key members of the gut microbiota in the …

Pathogen-driven degradation of endogenous and therapeutic antibodies during streptococcal infections

AG Toledo, E Bratanis, E Velásquez… - Nature …, 2023 - nature.com
Group A streptococcus (GAS) is a major bacterial pathogen responsible for both local and
systemic infections in humans. The molecular mechanisms that contribute to disease …

Dr. Jekyll and Mr. Hide: how Enterococcus faecalis subverts the host immune response to cause infection

PHN Kao, KA Kline - Journal of molecular biology, 2019 - Elsevier
Enterococcus faecalis, a ubiquitous member of the healthy human gut microbiota, is also a
common opportunistic pathogen and leading cause of nosocomial infections. This tenacious …

Milk glycans and their interaction with the infant-gut microbiota

N Kirmiz, RC Robinson, IM Shah… - Annual Review of …, 2018 - annualreviews.org
Human milk is a unique and complex fluid that provides infant nutrition and delivers an array
of bioactive molecules that serve various functions. Glycans, abundant in milk, can be found …

Endo-β-N-acetylglucosaminidases from infant gut-associated bifidobacteria release complex N-glycans from human milk glycoproteins

D Garrido, C Nwosu, S Ruiz-Moyano… - Molecular & Cellular …, 2012 - ASBMB
Breastfeeding is one of the main factors guiding the composition of the infant gut microbiota
in the first months of life. This process is shaped in part by the high amounts of human milk …

Characterization of the chitinolytic machinery of Enterococcus faecalis V583 and high-resolution structure of its oxidative CBM33 enzyme

G Vaaje-Kolstad, LA Bøhle, S Gåseidnes… - Journal of molecular …, 2012 - Elsevier
Little information exists for the ability of enterococci to utilize chitin as a carbon source. We
show that Enterococcus faecalis V583 can grow on chitin, and we describe two proteins, a …

EndoS2 is a unique and conserved enzyme of serotype M49 group A Streptococcus that hydrolyses N-linked glycans on IgG and α1-acid glycoprotein

J Sjögren, WB Struwe, EFJ Cosgrave… - Biochemical …, 2013 - portlandpress.com
Many bacteria have evolved ways to interact with glycosylation functions of the immune
system of their hosts. Streptococcus pyogenes [GAS (group A Streptococcus)] secretes the …