Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …

Lysosomal storage diseases are a group of metabolic disorders caused by deficiencies of
several components of lysosomal function. Most commonly affected are lysosomal …

Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during
which selected cellular components are transported to and broken down within lysosomes …

Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific,
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …

Membrane trafficking pathways are essential for the viability and growth of cells, and play a
major role in the interaction of cells with their environment. In this At a Glance article and …

The recent advancements in the knowledge of lysosomal biology and function have
translated into an improved understanding of the pathophysiology of …

Vesicular transport driven by membrane trafficking systems conserved in eukaryotes is
critical to cellular functionality and homeostasis. It is known that homotypic fusion and …

Multisubunit tethering complexes (MTCs) are multitasking hubs that form a link between
membrane fusion, organelle motility and signaling. CORVET, CHEVI and HOPS are MTCs of …

We present a high-quality de novo genome assembly (rheMacS) of the Chinese rhesus
macaque (Macaca mulatta) using long-read sequencing and multiplatform scaffolding …

The movement of proteins between cellular compartments requires the orchestrated actions
of many factors including Rab family GTPases, Soluble NSF Attachment protein REceptors …