In silico mining for antimalarial structure-activity knowledge and discovery of novel antimalarial curcuminoids
Malaria is a parasitic tropical disease that kills around 600,000 patients every year. The
emergence of resistant Plasmodium falciparum parasites to artemisinin-based combination …
emergence of resistant Plasmodium falciparum parasites to artemisinin-based combination …
Chemoselective Synthesis and Anti-Kinetoplastidal Properties of 2,6-Diaryl-4H-tetrahydro-thiopyran-4-one S-Oxides: Their Interplay in a Cascade of Redox …
T Gendron, DA Lanfranchi, NI Wenzel, H Kessedjian… - Molecules, 2024 - mdpi.com
2, 6-Diaryl-4 H-tetrahydro-thiopyran-4-ones and corresponding sulfoxide and sulfone
derivatives were designed to lower the major toxicity of their parent anti-kinetoplatidal …
derivatives were designed to lower the major toxicity of their parent anti-kinetoplatidal …
Macozinone: revised synthesis and crystal structure of a promising new drug for treating drug-sensitive and drug-resistant tuberculosis
G Zhang, CC Aldrich - Acta Crystallographica Section C: Structural …, 2019 - journals.iucr.org
Mycobacterium tuberculosis (Mtb), the principal etiological agent of tuberculosis (TB), infects
over one-quarter of humanity and is now the leading cause of infectious disease mortality by …
over one-quarter of humanity and is now the leading cause of infectious disease mortality by …
Thiopyrans and Their Benzo Derivatives
NR Candeias, A Efimov - … Heterocyclic Chemistry IV, 2021 - researchportal.tuni.fi
The chemistry of thiopyrans and their benzo derivatives are covered. Studies on structural
methods and elucidation of photochemical properties have been mentioned. Reactivity of six …
methods and elucidation of photochemical properties have been mentioned. Reactivity of six …
Cyclic sulfones from double conjugate addition of Rongalite
M Goga, H Zong, J Prana, R Michel, A Muro… - Synthetic …, 2023 - Taylor & Francis
Cyclic sulfones are obtained in up to 92% yield by double conjugate addition of Rongalite
(sodium hydroxymethyl sulfinate) to dienones. The major product in each case is the kinetic …
(sodium hydroxymethyl sulfinate) to dienones. The major product in each case is the kinetic …