Protein synthesis initiation in eukaryotic cells
WC Merrick, GD Pavitt - Cold Spring Harbor perspectives …, 2018 - cshperspectives.cshlp.org
This review summarizes our current understanding of the major pathway for the initiation
phase of protein synthesis in eukaryotic cells, with a focus on recent advances. We describe …
phase of protein synthesis in eukaryotic cells, with a focus on recent advances. We describe …
Targeting the translation machinery in cancer
Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and
tumour suppressors affect the translation machinery, making aberrant translation a …
tumour suppressors affect the translation machinery, making aberrant translation a …
mTOR coordinates protein synthesis, mitochondrial activity and proliferation
Protein synthesis is one of the most energy consuming processes in the cell. The
mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that …
mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that …
The scanning mechanism of eukaryotic translation initiation
AG Hinnebusch - Annual review of biochemistry, 2014 - annualreviews.org
In eukaryotes, the translation initiation codon is generally identified by the scanning
mechanism, wherein every triplet in the messenger RNA leader is inspected for …
mechanism, wherein every triplet in the messenger RNA leader is inspected for …
[HTML][HTML] Modulation of RNA condensation by the DEAD-box protein eIF4A
Stress granules are condensates of non-translating mRNAs and proteins involved in the
stress response and neurodegenerative diseases. Stress granules form in part through …
stress response and neurodegenerative diseases. Stress granules form in part through …
Mechanisms and regulation of RNA condensation in RNP granule formation
Ribonucleoprotein (RNP) granules are RNA–protein assemblies that are involved in
multiple aspects of RNA metabolism and are linked to memory, development, and disease …
multiple aspects of RNA metabolism and are linked to memory, development, and disease …
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
The large serine/threonine protein kinase mTOR regulates cellular and organismal
homeostasis by coordinating anabolic and catabolic processes with nutrient, energy, and …
homeostasis by coordinating anabolic and catabolic processes with nutrient, energy, and …
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation
AC Gingras, B Raught… - Annual review of …, 1999 - annualreviews.org
▪ Abstract Eukaryotic translation initiation factor 4F (eIF4F) is a protein complex that mediates
recruitment of ribosomes to mRNA. This event is the rate-limiting step for translation under …
recruitment of ribosomes to mRNA. This event is the rate-limiting step for translation under …
Molecular mechanism of scanning and start codon selection in eukaryotes
AG Hinnebusch - Microbiology and Molecular Biology Reviews, 2011 - Am Soc Microbiol
The correct translation of mRNA depends critically on the ability to initiate at the right AUG
codon. For most mRNAs in eukaryotic cells, this is accomplished by the scanning …
codon. For most mRNAs in eukaryotic cells, this is accomplished by the scanning …
Internal ribosome entry sites in eukaryotic mRNA molecules
CUT Hellen, P Sarnow - Genes & development, 2001 - genesdev.cshlp.org
Initiation of translation of most eukaryotic mRNAs commences with 5 end–dependent
recruitment of 40S ribosomal subunits to the mRNA. The 40S subunit carrying the initiator …
recruitment of 40S ribosomal subunits to the mRNA. The 40S subunit carrying the initiator …