Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

The WNT signaling pathway is a critical regulator of development and adult tissue
homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of …

Adult-stem-cell-derived organoids model human epithelial tissues ex vivo, which enables
the study of host–microbe interactions with great experimental control. This protocol …

Besides cardiomyocytes (CM), the heart contains numerous interstitial cell types which play
key roles in heart repair, regeneration and disease, including fibroblast, vascular and …

Multipotent stromal cells (MSCs) are vital for development, maintenance, function, and
regeneration of most tissues. They can differentiate along multiple connective lineages, but …

Intestinal stem cells (ISCs) are confined to crypt bottoms and their progeny differentiate near
crypt-villus junctions. Wnt and bone morphogenic protein (BMP) gradients drive this polarity …

Barrier epithelia depend upon resident stem cells for homeostasis, defense, and repair.
Epithelial stem cells of small and large intestines (ISCs) respond to their local …

Intestinal stem and progenitor cells replicate and differentiate in distinct compartments,
influenced by Wnt, BMP, and other subepithelial cues. The cellular sources of these signals …

The important and diverse roles of the gut microbiota in human health and disease are
increasingly recognized. The difficulty of inferring causation from metagenomic microbiome …

The high turnover and regenerative capacity of the adult intestine relies on resident stem
cells located at the bottom of the crypt. The enteric nervous system consists of an abundant …