Purpose: This review represents the current in vitro, in vivo animal and human researches
on the roles of IL-6 in inflammatory ocular disorders. Data sources were literature reviewed …

Background Uveitis consists of a spectrum of inflammatory disorders characterized by ocular
inflammation. The underlying pathophysiology consists of a complex interplay of various …

Background In 2012, a European initiative called S ingle Hub and Access point for pediatric
Rheumatology in Europe (SHARE) was launched to optimise and disseminate diagnostic …

Purpose Cystoid macular edema (CME) is a leading cause of blindness. This study
assessed the efficacy and safety of tocilizumab (TCZ) in refractory CME. Design …

Background Uveitis associated with juvenile idiopathic arthritis is a cause of major ocular
morbidity. A substantial proportion of children are refractory to systemic methotrexate and …

Purpose To report the primary endpoint analyses of the safety and efficacy of 2 different
doses of intravenous (IV) infusions of tocilizumab (TCZ), an IL-6 inhibitor, in eyes with …

Objective The Multinational Interdisciplinary Working Group for Uveitis in Childhood
identified the need to update the current guidelines, and the objective here was to produce …

Objective. To report on experience using the anti-interleukin 6 receptor antibody tocilizumab
(TCZ) to treat severe and therapy-refractory uveitis associated with juvenile idiopathic …

Background Uveitis in juvenile idiopathic arthritis (JIAU) is frequently associated with the
development of complications and visual loss. Topical corticosteroids are the first line …

Birdshot chorioretinopathy (BCR) is a rare form of chronic, bilateral, posterior uveitis with a
distinctive clinical phenotype, and a strong association with HLA-A29. It predominantly …