Summary von W illebrand factor (VWF) plays key roles in both primary and secondary
hemostasis by capturing platelets and chaperoning clotting factor VIII, respectively. It is …

Abstract Purpose of Review The accumulation of LDL in the arterial intima is an initiating
event in atherosclerosis. After decades of controversy, it is now clear that transcytosis of LDL …

Weibel-Palade body (WPB) exocytosis underlies hormone-evoked VWF secretion from
endothelial cells (ECs). We identify new endogenous components of the WPB: Rab3B …

The establishment and maintenance of polarized plasma membrane domains is essential
for cellular function and proper development of organisms. Epithelial cells polarize along …

Vascular endothelial cells contain unique rod-shaped secretory organelles, called Weibel-
Palade bodies (WPBs), which contain the hemostatic protein von Willebrand factor (VWF) …

Acidic clusters act as sorting signals for packaging cargo into clathrin-coated vesicles
(CCVs), and also facilitate down-regulation of MHC-I by HIV-1 Nef. To find acidic cluster …

Angiogenesis is crucial for cancer progression. While several anti-angiogenic drugs are in
use for cancer treatment, their clinical benefits are unsatisfactory. Thus, a deeper …

Insulin stimulates glucose transport in adipocytes by triggering translocation of GLUT4
glucose transporters to the plasma membrane (PM) and several Rabs including Rab10 have …

Dynamic endocytic and exocytic trafficking of integrins is an important mechanism for cell
migration, invasion, and cytokinesis. Endocytosis of integrin can be classified as clathrin …

During myogenesis, myogenic stem cells undergo several sequential events, including cell
division, migration, and cell-cell fusion, leading to the formation of multinuclear myotubes …