Engineered models to parse apart the metastatic cascade
While considerable progress has been made in studying genetic and cellular aspects of
metastasis with in vitro cell culture and in vivo animal models, the driving mechanisms of …
metastasis with in vitro cell culture and in vivo animal models, the driving mechanisms of …
Collagen as a biomaterial for skin and corneal wound healing
R Sklenářová, N Akla, MJ Latorre, J Ulrichová… - Journal of Functional …, 2022 - mdpi.com
The cornea and the skin are two organs that form the outer barrier of the human body. When
either is injured (eg, from surgery, physical trauma, or chemical burns), wound healing is …
either is injured (eg, from surgery, physical trauma, or chemical burns), wound healing is …
Constricted migration increases DNA damage and independently represses cell cycle
Cell migration through dense tissues or small capillaries can elongate the nucleus and even
damage it, and any impact on cell cycle has the potential to affect various processes …
damage it, and any impact on cell cycle has the potential to affect various processes …
Brain metastasization of breast cancer
T Custodio-Santos, M Videira, MA Brito - Biochimica et Biophysica Acta …, 2017 - Elsevier
Central nervous system metastases have been reported in 15–25% of breast cancer
patients, and the incidence is increasing. Moreover, the survival of these patients is …
patients, and the incidence is increasing. Moreover, the survival of these patients is …
[HTML][HTML] Interaction of magnetic fields with biogenic magnetic nanoparticles on cell membranes: Physiological consequences for organisms in health and disease
The interaction mechanisms between magnetic fields (MFs) and living systems, which
remained hidden for more than a hundred years, continue to attract the attention of …
remained hidden for more than a hundred years, continue to attract the attention of …
Biofabrication strategies and engineered in vitro systems for vascular mechanobiology
The vascular system is integral for maintaining organ‐specific functions and homeostasis.
Dysregulation in vascular architecture and function can lead to various chronic or acute …
Dysregulation in vascular architecture and function can lead to various chronic or acute …
Development of tumor-vasculature interaction on chip mimicking vessel co-option of glioblastoma
Vessel co-option (VC) differs from angiogenesis in that tumor cells grow toward blood
vessels. Through VC, tumor cells can receive relatively more nutrients and oxygen from …
vessels. Through VC, tumor cells can receive relatively more nutrients and oxygen from …
Endothelial PAI-1 (plasminogen activator inhibitor-1) blocks the intrinsic pathway of coagulation, inducing the clearance and degradation of FXIa (activated factor XI)
Objective—Activation of coagulation FXI (factor XI) by FXIIa (activated factor XII) is a
prothrombotic process. The endothelium is known to play an antithrombotic role by limiting …
prothrombotic process. The endothelium is known to play an antithrombotic role by limiting …
In vitro vascularization improves in vivo functionality of human engineered cardiac tissues
Engineered human cardiac tissues hold great promise for disease modeling, drug
development, and regenerative therapy. For regenerative applications, successful …
development, and regenerative therapy. For regenerative applications, successful …
Patterning vasculature: the role of biofabrication to achieve an integrated multicellular ecosystem
In regenerative medicine (RM), creating engineered tissues with functionally relevant
vasculature is a critical goal. Recent technological advances in biofabrication and …
vasculature is a critical goal. Recent technological advances in biofabrication and …