Persistent pain, which is poorly treated and estimated to afflict one third of the world's
population, is largely mediated by the sensitization of nociceptive neurons. This sensitization …

Dysfunction in regulation of mRNA translation is an increasingly recognized characteristic of
many diseases and disorders, including cancer, diabetes, autoimmunity …

Dorsal root ganglion (DRG) neurons detect sensory inputs and are crucial for pain
processing. They are often studied in vitro as dissociated cell cultures with the assumption …

In addition to treating depression, antidepressant drugs are also a first-line treatment for
neuropathic pain, which is pain secondary to lesion or pathology of the nervous system …

Neural communication between the brain and adipose tissues regulates energy expenditure
and metabolism through modulation of adipose tissue functions. We have recently …

Alternative polyadenylation (APA) is a molecular mechanism during a pre‐mRNA
processing that involves usage of more than one polyadenylation site (PA‐site) generating …

Background Paclitaxel is one of the most commonly used drugs to treat breast cancer. Its
major dose-limiting toxicity is paclitaxel-induced peripheral neuropathy (PIPN). PIPN …

The endoplasmic reticulum (ER) is highly conserved in eukaryotes and neurons. Indeed, the
localization of the organelle in axons has been known for nearly half a century. However, the …

Chemotherapy-induced peripheral neuropathy (CIPN) is a severe and dose-limiting side
effect of cancer treatment that affects millions of cancer survivors throughout the world and …

Clinically, osteoarthritis (OA) pain is significantly associated with synovial inflammation.
Identification of the mechanisms driving inflammation could reveal new targets to relieve this …