Progesterone: therapeutic opportunities for neuroprotection and myelin repair

M Schumacher, R Guennoun, DG Stein… - Pharmacology & …, 2007 - Elsevier
Progesterone and its metabolites promote the viability of neurons in the brain and spinal
cord. Their neuroprotective effects have been documented in different lesion models …

Membrane progesterone receptor expression in mammalian tissues: a review of regulation and physiological implications

GE Dressing, JE Goldberg, NJ Charles… - Steroids, 2011 - Elsevier
The recent discovery of a novel, membrane localized progestin receptor (mPR) unrelated to
the classical progesterone receptor (PR) in fishes and its subsequent identification in …

Crystal structures of the human adiponectin receptors

H Tanabe, Y Fujii, M Okada-Iwabu, M Iwabu… - Nature, 2015 - nature.com
Adiponectin stimulation of its receptors, AdipoR1 and AdipoR2, increases the activities of
5′ AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor …

Steroid and G protein binding characteristics of the seatrout and human progestin membrane receptor α subtypes and their evolutionary origins

P Thomas, Y Pang, J Dong, P Groenen, J Kelder… - …, 2007 - academic.oup.com
A novel progestin receptor (mPR) with seven-transmembrane domains was recently
discovered in spotted seatrout and homologous genes were identified in other vertebrates …

[HTML][HTML] High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions

D Hoepfner, SB Helliwell, H Sadlish, S Schuierer… - Microbiological …, 2014 - Elsevier
Due to evolutionary conservation of biology, experimental knowledge captured from genetic
studies in eukaryotic model organisms provides insight into human cellular pathways and …

Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor

ML Narasimhan, MA Coca, J Jin, T Yamauchi, Y Ito… - Molecular cell, 2005 - cell.com
The antifungal activity of the PR-5 family of plant defense proteins has been suspected to
involve specific plasma membrane component (s) of the fungal target. Osmotin is a tobacco …

Role of perivascular adipose tissue-derived adiponectin in vascular homeostasis

A Sowka, P Dobrzyn - Cells, 2021 - mdpi.com
Studies of adipose tissue biology have demonstrated that adipose tissue should be
considered as both passive, energy-storing tissue and an endocrine organ because of the …

Control of membrane fluidity: the OLE pathway in focus

S Ballweg, R Ernst - Biological Chemistry, 2017 - degruyter.com
The maintenance of a fluid lipid bilayer is key for membrane integrity and cell viability. We
are only beginning to understand how eukaryotic cells sense and maintain the characteristic …

Membrane progesterone receptors in reproduction and cancer

P Valadez-Cosmes, ER Vázquez-Martínez… - Molecular and cellular …, 2016 - Elsevier
Progesterone is a sexual steroid hormone that has a critical role in reproductive processes
in males and females of several species, including humans. Furthermore, progesterone has …

Fast glucocorticoid actions on brain: back to the future

MF Dallman - Frontiers in neuroendocrinology, 2005 - Elsevier
Rapid, non-transcriptionally mediated, effects of glucocorticoids affect many behaviors as
well as inhibition of function in the hypothalamo–pituitary–adrenal axis. In this short review, it …