AMPK: restoring metabolic homeostasis over space and time
E Trefts, RJ Shaw - Molecular cell, 2021 - cell.com
The evolution of AMPK and its homologs enabled exquisite responsivity and control of
cellular energetic homeostasis. Recent work has been critical in establishing the …
cellular energetic homeostasis. Recent work has been critical in establishing the …
AMPK: The key to ischemia‐reperfusion injury
J Cai, X Chen, X Liu, Z Li, A Shi, X Tang… - Journal of cellular …, 2022 - Wiley Online Library
Ischemia‐reperfusion injury (IRI) refers to a syndrome in which tissue damage is further
aggravated and organ function further deteriorates when blood flow is restored after a period …
aggravated and organ function further deteriorates when blood flow is restored after a period …
Effects of sex and aging on the immune cell landscape as assessed by single-cell transcriptomic analysis
Z Huang, B Chen, X Liu, H Li, L Xie… - Proceedings of the …, 2021 - National Acad Sciences
Sex and aging influence the human immune system, resulting in disparate responses to
infection, autoimmunity, and cancer. However, the impact of sex and aging on the immune …
infection, autoimmunity, and cancer. However, the impact of sex and aging on the immune …
Mapping of the plant SnRK1 kinase signalling network reveals a key regulatory role for the class II T6P synthase-like proteins
J Van Leene, D Eeckhout, A Gadeyne, C Matthijs… - Nature Plants, 2022 - nature.com
The central metabolic regulator SnRK1 controls plant growth and survival upon activation by
energy depletion, but detailed molecular insight into its regulation and downstream targets is …
energy depletion, but detailed molecular insight into its regulation and downstream targets is …
[HTML][HTML] CAMKK2 defines ferroptosis sensitivity of melanoma cells by regulating AMPK‒NRF2 pathway
S Wang, X Yi, Z Wu, S Guo, W Dai, H Wang… - Journal of Investigative …, 2022 - Elsevier
Melanoma is the most lethal skin cancer caused by the malignant transformation of
epidermal melanocytes. Recent progress in targeted therapy and immunotherapy has …
epidermal melanocytes. Recent progress in targeted therapy and immunotherapy has …
AMPK signaling and its targeting in cancer progression and treatment
The intrinsic mechanisms sensing the imbalance of energy in cells are pivotal for cell
survival under various environmental insults. AMP-activated protein kinase (AMPK) serves …
survival under various environmental insults. AMP-activated protein kinase (AMPK) serves …
Linking ROS levels to autophagy: the key role of AMPK
Oxygen reactive species (ROS) are a group of molecules generated from the incomplete
reduction of oxygen. Due to their high reactivity, ROS can interact with and influence the …
reduction of oxygen. Due to their high reactivity, ROS can interact with and influence the …
Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter
AMP-activated protein kinase (AMPK) is a master regulator of cellular energetics which
coordinates metabolism by phosphorylating a plethora of substrates throughout the cell. But …
coordinates metabolism by phosphorylating a plethora of substrates throughout the cell. But …
TBC1D23 mediates Golgi-specific LKB1 signaling
Y Tu, Q Yang, M Tang, L Gao, Y Wang, J Wang… - Nature …, 2024 - nature.com
Abstract Liver kinase B1 (LKB1), an evolutionarily conserved serine/threonine kinase, is a
master regulator of the AMPK subfamily and controls cellular events such as polarity …
master regulator of the AMPK subfamily and controls cellular events such as polarity …
SLC15A4 mediates M1-prone metabolic shifts in macrophages and guards immune cells from metabolic stress
T Kobayashi, D Nguyen-Tien… - Proceedings of the …, 2021 - National Acad Sciences
The amino acid and oligopeptide transporter Solute carrier family 15 member A4
(SLC15A4), which resides in lysosomes and is preferentially expressed in immune cells …
(SLC15A4), which resides in lysosomes and is preferentially expressed in immune cells …