RNA modification has recently become a significant process of gene regulation, and the
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …

Cancer was initially considered to be an exclusively genetic disease, but an interplay of
dysregulated genetic and epigenetic mechanisms is now known to contribute to the cancer …

The biological functions of noncoding RNA N 6-methyladenosine (m6A) modification remain
poorly understood. In the present study, we depict the landscape of super-enhancer RNA …

While epigenetic modifications of DNA and histones play main roles in gene transcription
regulation, recently discovered post-transcriptional RNA modifications, known as …

Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

Eukaryotic genomes are prevalently transcribed into many types of RNAs that translate into
proteins or execute gene regulatory functions. Many RNAs associate with chromatin directly …

The mechanisms by which environmentally-induced epiphenotypes are transmitted
transgenerationally in mammals are poorly understood. Here we show that exposure of …

Transposable elements (TEs) are parasitic DNA sequences accounting for over half of the
human genome. Tight control of the repression and activation states of TEs is critical for …

Numerous strategies are employed by cancer cells to control gene expression and facilitate
tumorigenesis. In the study of epitranscriptomics, a diverse set of modifications to RNA …

Abstract Background Circular RNAs (circRNAs) play important roles in the occurrence and
development of cancer and chemoresistance. DNA damage repair contributes to the …