Accurate diagnosis of orthopedic infection is crucial in guiding both antimicrobial therapy
and surgical management in order to optimize patient outcomes. A variety of microbiological …

Metagenomic next-generation sequencing (mNGS) is a novel tool for identifying microbial
DNA and/or RNA in blood and other clinical specimens. In the face of increasingly complex …

As a result of the increasing use of improved detection methods, Kingella kingae, a Gram-
negative component of the pediatric oropharyngeal microbiota, is increasingly appreciated …

This clinical practice guideline for the diagnosis and treatment of acute bacterial arthritis
(ABA) in children was developed by a multidisciplinary panel representing the Pediatric …

Primary spinal infection (PSI) is a generic term covering a heterogeneous group of infections
that can affect the vertebral body, intervertebral disks, the content of the medullary cavity …

Background Native joint septic arthritis (NJSA) is definitively diagnosed by a positive Gram
stain or culture, along with supportive clinical findings. Preoperative antibiotics are known to …

Background: Osteomyelitis causes marked disability and is one of the most challenging
diseases for orthopaedists to treat because of the considerable rate of infection recurrence …

Highlights What are the main findings? Although there was a high concordance between
methodologies, a hybridization-capture-based mNGS workflow was able to detect 29 …

Background Rapid and accurate identification of pathogens is very important for the
treatment of Severe community-acquired pneumonia (SCAP) in children. Metagenomic Next …

In recent years, advancements in modern laboratory diagnostics have identified Kingella
kingae (K. kingae) as the major cause of osteoarticular infections in early childhood. The …