This work presents the results of using tree-based models, including Gradient Boosting,
Extra Trees, and Random Forest, to model the solubility of hyoscine drug and solvent …

Abstract Ibrutinib (PCI-32765), marketed under the trade name IMBRUVICA, is a first-in-
class irreversible inhibitor drug of Bruton tyrosine kinase (BTK). In the current research, its …

Chlorothiazide, with the brand name Diuril, is used as a diuretic as well as an
antihypertensive drug. This medicine with very slight solubility in water and low permeability …

With the advent of the aging society, osteoporosis (OP) risk increases yearly. Currently, the
clinical usage of anti-OP drugs is challenged by recurrent side effects and poor patient …

Metformin, as an anti-hyperglycemic, is the main medicine for treating diabetes of type II.
However, its daily dose is high due to its incomplete absorption and short half-life, which …

The effective use of the supercritical technology in the production of new pharmaceutical
formulations with greater bioavailability requires the determination of the solubility of …

In this research, solubility of Hyoscine, as the most well-known drugs used to relieve
spasmodic abdominal pain, in supercritical carbon dioxide (scCO 2) was determined at 170 …

Background/purpose Chlorothiazide is a well-known diuretic and an antihypertensive drug
with poor solubility and permeability and thus low bioavailability. Producing nanoparticles of …

Variability of drug solubility in supercritical solvent was investigated theoretically in this study
using multiple machine learning models. The method of supercritical preparation can be …

With the excessive use of fossil energy and concern for environmental protection, biomass
gasification as an effective means of biomass energy utilization has received widespread …