The nuclear compartment is delimited by a specialized expanded sheet of the endoplasmic
reticulum (ER) known as the nuclear envelope (NE). Compared to the outer nuclear …

Budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe
are good models for heterochromatin study. In S. pombe, H3K9 methylation and Swi6, an …

During cell division, remodelling of the nuclear envelope enables chromosome segregation
by the mitotic spindle. The reformation of sealed nuclei requires ESCRTs (endosomal …

Endosomal sorting complexes required for transport III (ESCRT-III) proteins have been
implicated in sealing the nuclear envelope in mammals, spindle pole body dynamics in …

Spatially and functionally distinct domains of heterochromatin and euchromatin play
important roles in the maintenance of chromosome stability and regulation of gene …

Eukaryotic genomes are organized within the nucleus through interactions with inner
nuclear membrane (INM) proteins. How chromatin tethering to the INM is controlled in …

The nuclear envelope (NE) is a double-membrane structure consisting of inner and outer
membranes that spatially separate the nucleus from the cytoplasm, and its function is critical …

Maintaining the integrity of the nuclear envelope (NE) is essential for preventing genomic
DNA damage. Recent studies have shown that enzymes that catalyze lipid synthesis are …

The nuclear envelope (NE) undergoes dynamic remodeling to maintain NE integrity, a
process involving the inner nuclear membrane protein LEM2 recruiting CHMP7/Cmp7 and …

The nuclear envelope (NE) continues to the endoplasmic reticulum (ER). Proper partitioning
of NE and ER is crucial for cellular activity, but the key factors maintaining the boundary …