Carotid bodies and the integrated cardiorespiratory response to hypoxia

BG Lindsey, SC Nuding, LS Segers, KF Morris - Physiology, 2018 - journals.physiology.org
Advances in our understanding of brain mechanisms for the hypoxic ventilatory response,
coordinated changes in blood pressure, and the long-term consequences of chronic …

Brainstem mechanisms underlying the cough reflex and its regulation

D Mutolo - Respiratory physiology & neurobiology, 2017 - Elsevier
Cough is a very important airway protective reflex. Cough-related inputs are conveyed to the
caudal nucleus tractus solitarii (cNTS) that projects to the brainstem respiratory network. The …

Coordination of cough and swallow: a meta-behavioral response to aspiration

T Pitts, MJ Rose, AN Mortensen, I Poliacek… - Respiratory physiology …, 2013 - Elsevier
Airway protections is the prevention and/or removal of material by behaviors such as cough
and swallow. We hypothesized these behaviors are coordinated to respond to aspiration …

Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs

YL Chou, N Mori, BJ Canning - American Journal of …, 2018 - journals.physiology.org
We have addressed the hypothesis that the opposing effects of bronchopulmonary C-fiber
activation on cough are attributable to the activation of C-fiber subtypes. Coughing was …

Physiological and pathophysiological interactions between the respiratory central pattern generator and the sympathetic nervous system

YI Molkov, DB Zoccal, DM Baekey, APL Abdala… - Progress in brain …, 2014 - Elsevier
Respiratory modulation seen in the sympathetic nerve activity (SNA) implies that the
respiratory and sympathetic networks interact. During hypertension elicited by chronic …

Role of the dorsal medulla in the neurogenesis of airway protection

DC Bolser, TE Pitts, PW Davenport, KF Morris - Pulmonary pharmacology & …, 2015 - Elsevier
The dorsal medulla encompassing the nucleus of the tractus solitarius (NTS) and
surrounding reticular formation (RF) has an important role in processing sensory information …

NMDA and GABA receptors as potential targets in cough hypersensitivity syndrome

KF Chung - Current Opinion in Pharmacology, 2015 - Elsevier
Highlights•Chronic cough is now regarded as part of a cough hypersensitivity
syndrome.•Afferent signals in brain nuclei may be amplified by neuropathic inflammation.•N …

M4 muscarinic receptors mediate acetylcholine-induced suppressant effects on the cough reflex in the caudal nucleus tractus solitarii of the rabbit

E Cinelli, L Iovino, F Bongianni… - … of Physiology-Lung …, 2023 - journals.physiology.org
It has been shown that muscarinic acetylcholine receptors (mAChRs) located within the
caudal nucleus tractus solitarii (cNTS) mediate a cholinergic inhibitory control mechanism of …

A joint computational respiratory neural network-biomechanical model for breathing and airway defensive behaviors

R O'Connor, LS Segers, KF Morris, SC Nuding… - Frontiers in …, 2012 - frontiersin.org
Data-driven computational neural network models have been used to study mechanisms for
generating the motor patterns for breathing and breathing related behaviors such as …

Effects of ion channel noise on neural circuits: an application to the respiratory pattern generator to investigate breathing variability

H Yu, RR Dhingra, TE Dick… - Journal of …, 2017 - journals.physiology.org
Neural activity generally displays irregular firing patterns even in circuits with apparently
regular outputs, such as motor pattern generators, in which the output frequency fluctuates …