Alterations in olfactory functions are proposed to be early biomarkers for neurodegeneration.
Many neurodegenerative diseases are age-related, including two of the most common …

The validity of widely used rodent behavioural tests of anxiety has been questioned, as they
often fail to produce consistent results across independent replicate studies. In this study, we …

Stressful experiences are linked to anxiety disorders in humans. Similar effects are observed
in rodent models, where anxiety is often measured in classic conflict tests such as the open …

The inflammasome is hypothesized to be a key mediator of the response to physiological
and psychological stressors, and its dysregulation may be implicated in major depressive …

An animal model of human behavior represents a complex of cognitive and/or emotional
processess, which are translated from animals to humans. A behavioral test is developed …

Handling laboratory animals during test procedures is an important source of stress that may
impair reliability of test responses. Picking up mice by the tail is aversive, stimulating stress …

The reproducibility crisis (or replication crisis) in biomedical research is a particularly
existential and under-addressed issue in the field of behavioral neuroscience, where, in …

In humans, infancy and adolescence are associated with major changes in synaptic
functions and ongoing maturation of neural networks, which underlie the major behavioral …

The vast majority of drugs entering human trials fail. This problem (called “attrition”) is widely
recognized as a public health crisis, and has been discussed openly for the last two …

An important factor in reducing variability in mouse test outcomes has been to develop
assays that can be used for continuous automated home cage assessment. Our experience …