Reactive oxygen species (ROS) are produced in cells during metabolic processes.
Excessive intracellular ROS may react with large biomolecules, such as DNA, RNA …

Acute ischemic stroke is a common cause of morbidity and mortality worldwide.
Thrombolysis with recombinant tissue plasminogen activator and endovascular …

Succinate dehydrogenase (SDH) has been classically considered a mitochondrial enzyme
with the unique property to participate in both the citric acid cycle and the electron transport …

Oxidative stress is an increase in the reduction potential or a large decrease in the reducing
capacity of the cellular redox couples. A particularly destructive aspect of oxidative stress is …

Cancer cells are characterized by self-sufficiency in the absence of growth signals, their
ability to evade apoptosis, resistance to anti-growth signals, sustained angiogenesis …

Apoptosis mediates the precise and programmed natural death of neurons and is a
physiologically important process in neurogenesis during maturation of the central nervous …

In this study, the anticancer effect of icariin, a natural flavonol glycoside, against human
hepatoma SMMC-7721 cells and the underlying mechanisms were investigated. Icariin …

With the arrival of the third millennium, in spite of unprecedented progress in molecular
medicine, cancer remains as untamed as ever. The complexity of tumours, dictating the …

Mitochondria are emerging as idealized targets for anti-cancer drugs. One reason for this is
that although these organelles are inherent to all cells, drugs are being developed that …

Mitochondrial alterations have been associated with the cytotoxic effect of 6-
hydroxydopamine (6-OHDA), a widely used neurotoxin to study Parkinson's disease. Herein …