Vitamin C is an essential micronutrient for humans, with pleiotropic functions related to its
ability to donate electrons. It is a potent antioxidant and a cofactor for a family of biosynthetic …

Neutrophils are essential for killing bacteria and other microorganisms, and they also have a
significant role in regulating the inflammatory response. Stimulated neutrophils activate their …

This review will briefly outline the major signaling pathways in PMA-activated neutrophils.
PMA is widely used to understand neutrophil pathways and formation of NETs. PMA …

Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells that can
be isolated from many adult tissues. They can differentiate into cells of the mesodermal …

In the phagocytosis field, ROS production by the phagocyte NOX has been associated with
pathogen killing for the last 50 years. Since the discovery of nonphagocyte NOX, numerous …

Neutrophils engulf and kill bacteria when their antimicrobial granules fuse with the
phagosome. Here, we describe that, upon activation, neutrophils release granule proteins …

Neutrophil extracellular traps (NETs) are extracellular chromatin structures that can trap and
degrade microbes. They arise from neutrophils that have activated a cell death program …

Neutrophil extracellular traps (NETs) are extracellular structures composed of chromatin and
granule proteins that bind and kill microorganisms. We show that upon stimulation, the …

Neutrophil extracellular traps (NETs) facilitate the extracellular killing of pathogens.
However, in recent years, excessive NET formation has been implicated in several …

Neutrophil extracellular traps (NETs) are chromatin structures loaded with antimicrobial
molecules. They can trap and kill various bacterial, fungal and protozoal pathogens, and …