Diabetic retinopathy (DR) is a common diabetic complication and the main cause of
blindness worldwide, which seriously affects the quality of life of patients. Studies have …

P-type ATPase are present in nearly all organisms. They maintain electrochemical gradients
for many solutes, in particular ions, they control membrane lipid asymmetry, and are crucial …

Despite advances in cardioprotection, new therapeutic strategies capable of preventing
ischemia-reperfusion injury of patients are still needed. Here, we discover that sarcoplasmic …

Secretory pathway Ca2+/Mn2+ ATPase 1 (SPCA1) actively transports cytosolic Ca2+ and
Mn2+ into the Golgi lumen, playing a crucial role in cellular calcium and manganese …

Sarcoendoplasmic reticulum calcium ATPase (SERCA), a member of the P-type ATPase
family of ion and lipid pumps, is responsible for the active transport of Ca2+ from the …

Calcium ions (Ca2+) are prominent cell signaling effectors that regulate a wide variety of
cellular processes. Among the different players in Ca2+ homeostasis, primary active Ca2+ …

The sarco/endoplasmic reticulum calcium ATPase (SERCA), which plays a key role in the
maintenance of Ca2+ ion homeostasis, is an extensively studied enzyme, the inhibition of …

Abstract Sarco/endoplasmic reticulum Ca2+ ATPase 2b (SERCA2b), a member of the
SERCA family, is expressed ubiquitously and transports Ca2+ into the sarco/endoplasmic …

The biogenesis of chitin, a major structural polysaccharide found in the cuticle and
peritrophic matrix, is crucial for insect growth and development. Chitin synthase, a …

Under physiological conditions, most Ca2+-ATPase (SERCA) molecules bind ATP before
binding the Ca2+ transported. SERCA has a high affinity for ATP even in the absence of …