[HTML][HTML] Improving genetic association studies with a novel methodology that unveils the hidden complexity of all-cause heart failure

JT Gregg, BE Himes, FW Asselbergs, JH Moore - medRxiv, 2023 - ncbi.nlm.nih.gov
Results: Our method identified over 100 main GWAS effects that were consistent with prior
studies and hundreds of novel gene-by-smoking interactions, which collectively accounted …

APPROACHES TO MODEL GENETIC AND GENE-BY-ENVIRONMENT INTERACTIONS UNDERLYING COMPLEX TRAITS USING LATENT FEATURES

J Gregg - 2023 - repository.upenn.edu
This thesis develops methods that address the underlying reasons for inefficient SNP
discovery in GWAS. After developing methods that remove outliers and simulate Linkage …