Functional amyloids are a rapidly expanding class of fibrillar protein structures, with a core
cross-β scaffold, where novel and advantageous biological function is generated by the …

Melanosomes are unique organelles in melanocytes that produce melanin, the pigment for
skin, hair, and eye color. Tyrosinase is the essential and rate-limiting enzyme for melanin …

Aldehydes fixation was accidentally discovered in the early 20th century and soon became a
widely adopted practice in the histological field, due to an excellent staining enhancement in …

Protein aggregation is a feature of numerous neurodegenerative diseases. However,
regulated, often reversible, formation of protein aggregates, also known as condensates …

Amyloids are highly ordered fibrous cross-β protein aggregates that are notorious primarily
because of association with a variety of incurable human and animal diseases (termed …

Parkinson's disease (PD) is a neurodegenerative disorder associated with the death of
dopaminergic neurons within the substantia nigra of the brain. Melanoma is a cancer of …

Simple Summary The frequency of use of permanent hair dyes to change natural colour are
associated with fibre damage and with an increased risk of serious health problems. The …

It was recently shown (Sampson et al., Elife 9, 2020) that an amyloidogenic protein, CsgA,
present in E. coli biofilms in the gut can trigger Parkinson's disease in mice. This study …

Abstract The “Acute Myeloid Leukemia with gene mutations''group includes mutations in
Nucleophosmin 1 (NPM1) that is an abundant multifunctional protein with chaperon …

Abstract Mahogunin Ring Finger 1 (MGRN1) is an E3-ubiquitin ligase absent in dark-furred
mahoganoid mice. We investigated the mechanisms of hyperpigmentation in Mgrn1-null …