In recent years, major advances have been made in the understanding of the cellular and
molecular mechanisms driving pulmonary vascular remodelling in various forms of …

Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …

Obesity promotes diverse pathologies, including atherosclerosis and dementia, which
frequently involve vascular defects and endothelial cell (EC) dysfunction. Each organ has …

The respiratory system's complex cellular heterogeneity presents unique challenges to
researchers in this field. Although bulk RNA sequencing and single-cell RNA sequencing …

The physiological functions of endothelial cells control vascular tone, permeability,
inflammation, and angiogenesis, which significantly help to maintain a healthy vascular …

Endothelial cells (ECs) constitute the inner lining of vascular beds in mammals and are
crucial for homeostatic regulation of blood vessel physiology, but also play a key role in …

Pulmonary vascular remodeling is the critical structural alteration and pathological feature in
pulmonary hypertension (PH) and involves changes in the intima, media and adventitia …

The dysfunctional immune response and multiple organ injury in sepsis is a recurrent theme
impacting prognosis and mortality, while the lung is the first organ invaded by sepsis. To …

Abstract Background Creeping fat (CrF) has been recognized to play a positive role in
Crohn's disease (CD) progression, yet the cellular compositions within mesenteric adipose …

Pulmonary microbial diversity may be influenced by biotic or abiotic conditions (eg, disease,
smoking, invasive mechanical ventilation (MV), etc.). Specially, invasive MV may trigger …