Haematological malignancies were previously thought to be driven solely by genetic or
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …

Research in the last few years has revealed a sophisticated interaction network between
multiple bone marrow cells that regulate different hematopoietic stem cell (HSC) properties …

Increased microvessel density contributes to abnormal BM and spleen microenvironment in
myelofibrosis (MF). Taking advantage of the JAK2 V617F mutation as a marker of …

Myeloproliferative neoplasms (MPNs) are characterized by the clonal expansion of one or
more myeloid cell lineage. In most cases, proliferation of the malignant clone is ascribed to …

Knowledge about the hematopoietic niche has evolved considerably in recent years, in
particular through in vitro analyzes, mouse models and the use of xenografts. Its complexity …

Recently, the BM has been shown to play a key role in regulating the survival and function of
memory T cells. However, the impact of aging on these processes has not yet been studied …

Since early seventies of the twentieth century, through seminal work of Judah Folkman,
angiogenesis, the process of new blood vessel sprouting from the existing vasculature, was …

Cytokines are well known mediators of numerous physiological and pathological processes.
They contribute to the regulation of normal hematopoiesis but increasing data suggest that …

Simple Summary MPN blood cancers are characterized by elevated blood cell counts.
Chronic inflammation drives MPNs, which after 10–30 years, may lead to bone marrow …

BCR:: ABL1 negative myeloproliferative neoplasms (MPN) form a distinct group of
hematologic malignancies characterized by sustained proliferation of cells from multiple …