Sensitivity analysis of a multi‐physics model for the vascular microenvironment

P Vitullo, L Cicci, L Possenti, A Coclite… - … journal for numerical …, 2023 - Wiley Online Library
The vascular microenvironment is the scale at which microvascular transport, interstitial
tissue properties and cell metabolism interact. The vascular microenvironment has been …

[HTML][HTML] Nonlinear model order reduction for problems with microstructure using mesh informed neural networks

P Vitullo, A Colombo, NR Franco, A Manzoni… - Finite Elements in …, 2024 - Elsevier
Many applications in computational physics involve approximating problems with
microstructure, characterized by multiple spatial scales in their data. However, these …

Modeling hypoxia-induced radiation resistance and the impact of radiation sources

L Possenti, P Vitullo, A Cicchetti, P Zunino… - Computers in Biology …, 2024 - Elsevier
Hypoxia contributes significantly to resistance in radiotherapy. Our research rigorously
examines the influence of microvascular morphology on radiotherapy outcome, specifically …

Geometrically reduced modelling of pulsatile flow in perivascular networks

C Daversin-Catty, IG Gjerde, ME Rognes - Frontiers in Physics, 2022 - frontiersin.org
Flow of cerebrospinal fluid in perivascular spaces is a key mechanism underlying brain
transport and clearance. In this paper, we present a mathematical and numerical formalism …

Mesh-informed neural networks for operator learning in finite element spaces

NR Franco, A Manzoni, P Zunino - Journal of Scientific Computing, 2023 - Springer
Thanks to their universal approximation properties and new efficient training strategies,
Deep Neural Networks are becoming a valuable tool for the approximation of mathematical …

Modelling the Tumour Microenvironment, but What Exactly Do We Mean by “Model”?

CC Reyes-Aldasoro - Cancers, 2023 - mdpi.com
Simple Summary The word “model” can be used with different meanings and different
contexts, like a model student, clay models or a model railway. In some cases, the context …

Deep learning enhanced cost-aware multi-fidelity uncertainty quantification of a computational model for radiotherapy

P Vitullo, NR Franco, P Zunino - arXiv preprint arXiv:2402.08494, 2024 - arxiv.org
Forward uncertainty quantification (UQ) for partial differential equations is a many-query task
that requires a significant number of model evaluations. The objective of this work is to …

Modeling oxygen transport in the brain: An efficient coarse-grid approach to capture perivascular gradients in the parenchyma

D Pastor-Alonso, M Berg, F Boyer… - PLoS Computational …, 2024 - journals.plos.org
Recent progresses in intravital imaging have enabled highly-resolved measurements of
periarteriolar oxygen gradients (POGs) within the brain parenchyma. POGs are increasingly …

Reduced Lagrange multiplier approach for non-matching coupling of mixed-dimensional domains

L Heltai, P Zunino - arXiv preprint arXiv:2303.10600, 2023 - arxiv.org
Many physical problems involving heterogeneous spatial scales, such as the flow through
fractured porous media, the study of fiber-reinforced materials, or the modeling of the small …

[PDF][PDF] Learning operators with mesh-informed neural networks

NR Franco, A Manzoni, P Zunino - arXiv preprint arXiv …, 2022 - researchgate.net
Thanks to their universal approximation properties and new efficient training strategies,
Deep Neural Networks are becoming a valuable tool for the approximation of mathematical …