Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
Hyaluronan as an immune regulator in human diseases
Accumulation and turnover of extracellular matrix components are the hallmarks of tissue
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …
Extracting a biologically relevant latent space from cancer transcriptomes with variational autoencoders
The Cancer Genome Atlas (TCGA) has profiled over 10,000 tumors across 33 different
cancer-types for many genomic features, including gene expression levels. Gene …
cancer-types for many genomic features, including gene expression levels. Gene …
Hyaluronan: biosynthesis and signaling
Background Hyaluronan is a critical component of extracellular matrix with several different
roles. Besides the contribution to the tissue hydration, mechanical properties and correct …
roles. Besides the contribution to the tissue hydration, mechanical properties and correct …
Transmembrane pickets connect cyto-and pericellular skeletons forming barriers to receptor engagement
Phagocytic receptors must diffuse laterally to become activated upon clustering by
multivalent targets. Receptor diffusion, however, can be obstructed by transmembrane …
multivalent targets. Receptor diffusion, however, can be obstructed by transmembrane …
Extracellular matrix of the central nervous system: from neglect to challenge
DR Zimmermann, MT Dours-Zimmermann - Histochemistry and cell …, 2008 - Springer
The basic concept, that specialized extracellular matrices rich in hyaluronan, chondroitin
sulfate proteoglycans (aggrecan, versican, neurocan, brevican, phosphacan), link proteins …
sulfate proteoglycans (aggrecan, versican, neurocan, brevican, phosphacan), link proteins …
Diverse plasma membrane protrusions act as platforms for extracellular vesicle shedding
K Rilla - Journal of Extracellular Vesicles, 2021 - Wiley Online Library
Plasma membrane curvature is an important factor in the regulation of cellular phenotype
and is critical for various cellular activities including the shedding of extracellular vesicles …
and is critical for various cellular activities including the shedding of extracellular vesicles …
Pathogenesis of glaucoma: Extracellular matrix dysfunction in the trabecular meshwork‐A review
KE Keller, DM Peters - Clinical & experimental ophthalmology, 2022 - Wiley Online Library
The trabecular meshwork regulates aqueous humour outflow from the anterior chamber of
the eye. It does this by establishing a tunable outflow resistance, defined by the interplay …
the eye. It does this by establishing a tunable outflow resistance, defined by the interplay …
4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3
A Kultti, S Pasonen-Seppänen, M Jauhiainen… - Experimental cell …, 2009 - Elsevier
Hyaluronan accumulation on cancer cells and their surrounding stroma predicts an
unfavourable disease outcome, suggesting that hyaluronan enhances tumor growth and …
unfavourable disease outcome, suggesting that hyaluronan enhances tumor growth and …
Hyaluronan-dependent pericellular matrix
SP Evanko, MI Tammi, RH Tammi, TN Wight - Advanced drug delivery …, 2007 - Elsevier
Hyaluronan is a multifunctional glycosaminoglycan that forms the structural basis of the
pericellular matrix. Hyaluronan is extruded directly through the plasma membrane by one of …
pericellular matrix. Hyaluronan is extruded directly through the plasma membrane by one of …