Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets

B Wang, L Wu, J Chen, L Dong, C Chen… - Signal transduction and …, 2021 - nature.com
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Cardiovascular effects and safety of (non-aspirin) NSAIDs

AM Schjerning, P McGettigan, G Gislason - Nature Reviews Cardiology, 2020 - nature.com
Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective, widely used analgesics. For
the past 2 decades, considerable attention has been focused on their cardiovascular safety …

Home as the new frontier for the treatment of COVID-19: the case for anti-inflammatory agents

N Perico, M Cortinovis, F Suter… - The Lancet Infectious …, 2023 - thelancet.com
Summary COVID-19, caused by SARS-CoV-2, is characterised by a broad spectrum of
symptom severity that requires varying amounts of care according to the different stages of …

Lessons from 20 years with COX‐2 inhibitors: Importance of dose–response considerations and fair play in comparative trials

CO Stiller, P Hjemdahl - Journal of Internal Medicine, 2022 - Wiley Online Library
Nonsteroidal anti‐inflammatory drugs (NSAIDs) inhibit the enzyme cyclooxygenase (COX),
which forms prostaglandins involved in pain and inflammation. COX inhibitors have …

Non-steroidal anti-inflammatory drugs: Recent advances in the use of synthetic COX-2 inhibitors

M Ahmadi, S Bekeschus, KD Weltmann… - RSC Medicinal …, 2022 - pubs.rsc.org
Cyclooxygenase (COX) enzymes comprise COX-1 and COX-2 isoforms and are responsible
for prostaglandin production. Prostaglandins have critical roles in the inflammation pathway …

Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.

N Bhala, J Emberson, A Merhi, S Abramson… - Lancet (London …, 2013 - europepmc.org
Background The vascular and gastrointestinal effects of non-steroidal anti-inflammatory
drugs (NSAIDs), including selective COX-2 inhibitors (coxibs) and traditional non-steroidal …

New insights into the use of currently available non-steroidal anti-inflammatory drugs

K Brune, P Patrignani - Journal of pain research, 2015 - Taylor & Francis
Non-steroidal anti-inflammatory drugs (NSAIDs), which act via inhibition of the
cyclooxygenase (COX) isozymes, were discovered more than 100 years ago. They remain a …

Rheumatoid arthritis: recent advances on its etiology, role of cytokines and pharmacotherapy

J Alam, I Jantan, SNA Bukhari - Biomedicine & pharmacotherapy, 2017 - Elsevier
An autoimmune disease is defined as a clinical syndrome resulted from an instigation of
both T cell and B cell or individually, in the absence of any present infection or any sort of …

[图书][B] Deadly medicines and organised crime: how big pharma has corrupted healthcare

P Gotzsche - 2019 - taylorfrancis.com
PRESCRIPTION DRUGS ARE THE THIRD LEADING CAUSE OF DEATH AFTER HEART
DISEASE AND CANCER. In his latest ground-breaking book, Peter C Gotzsche exposes the …

Use of NSAIDs in treating patients with arthritis

LJ Crofford - Arthritis research & therapy, 2013 - Springer
Patients with rheumatic diseases, including rheumatoid arthritis and osteoarthritis, almost
universally describe pain and stiffness as important contributors to reduced health-related …