Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult
haematopoietic system. Understanding how early haematopoietic development occurs is of …

There are now many reports of human kidney organoids generated via the directed
differentiation of human pluripotent stem cells (PSCs) based on an existing understanding of …

The ontogeny of human haematopoietic stem cells (HSCs) is poorly defined owing to the
inability to identify HSCs as they emerge and mature at different haematopoietic sites. Here …

Aberrant inflammation in the CNS has been implicated as a major player in the
pathogenesis of human neurodegenerative disease. We developed a new approach to …

Clinical successes demonstrated by chimeric antigen receptor T-cell immunotherapy have
facilitated further development of T-cell immunotherapy against wide variety of diseases …

A variety of tissue lineages can be differentiated from pluripotent stem cells by mimicking
embryonic development through stepwise exposure to morphogens, or by conversion of one …

Human pluripotent stem cell (hPSC)-derived kidney organoids may facilitate disease
modeling and the generation of tissue for renal replacement. Long-term application …

Neutrophils, the most abundant white blood cells in circulation, are closely related to cancer
development and progression. Healthy primary neutrophils present potent cytotoxicity …

Developmental pathways that orchestrate the fleeting transition of endothelial cells into
haematopoietic stem cells remain undefined. Here we demonstrate a tractable approach for …

Definitive haematopoietic stem and progenitor cells (HSPCs) generate erythroid, lymphoid
and myeloid lineages. HSPCs are produced in the embryo via transdifferentiation of …