Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a systemic infection

A Synowiec, A Szczepański… - Clinical microbiology …, 2021 - Am Soc Microbiol
To date, seven identified coronaviruses (CoVs) have been found to infect humans; of these,
three highly pathogenic variants have emerged in the 21st century. The newest member of …

Hosts and sources of endemic human coronaviruses

VM Corman, D Muth, D Niemeyer, C Drosten - Advances in virus research, 2018 - Elsevier
The four endemic human coronaviruses HCoV-229E,-NL63,-OC43, and-HKU1 contribute a
considerable share of upper and lower respiratory tract infections in adults and children …

Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells

N Zhu, W Wang, Z Liu, C Liang, W Wang, F Ye… - Nature …, 2020 - nature.com
Abstract SARS-CoV-2, a β-coronavirus, has rapidly spread across the world, highlighting its
high transmissibility, but the underlying morphogenesis and pathogenesis remain poorly …

TMPRSS2 is a functional receptor for human coronavirus HKU1

N Saunders, I Fernandez, C Planchais, V Michel… - Nature, 2023 - nature.com
Four endemic seasonal human coronaviruses causing common colds circulate worldwide:
HKU1, 229E, NL63 and OC43 (ref.). After binding to cellular receptors, coronavirus spike …

An overview on the seven pathogenic human coronaviruses

MM Kesheh, P Hosseini, S Soltani… - Reviews in Medical …, 2022 - Wiley Online Library
To date, seven human coronaviruses (HCoVs) have been detected: HCoV‐NL63, HCoV‐
229E, HCoV‐HKU1, HCoV‐OC43, severe acute respiratory syndrome coronavirus (SARS …

The duration of infectiousness of individuals infected with SARS-CoV-2

KA Walsh, S Spillane, L Comber, K Cardwell… - Journal of Infection, 2020 - Elsevier
Objectives To summarise the evidence on the duration of infectiousness of individuals in
whom SARS-CoV-2 ribonucleic acid is detected. Methods A rapid review was undertaken in …

Coronaviruses—drug discovery and therapeutic options

A Zumla, JFW Chan, EI Azhar, DSC Hui… - Nature reviews Drug …, 2016 - nature.com
In humans, infections with the human coronavirus (HCoV) strains HCoV-229E, HCoV-OC43,
HCoV-NL63 and HCoV-HKU1 usually result in mild, self-limiting upper respiratory tract …

Broad-spectrum coronavirus antiviral drug discovery

AL Totura, S Bavari - Expert opinion on drug discovery, 2019 - Taylor & Francis
Introduction: The highly pathogenic coronaviruses severe acute respiratory syndrome
coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) …

Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal …

J Kindrachuk, B Ork, S Mazur… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus,
and infections with this virus can result in acute respiratory syndrome with renal failure …

[HTML][HTML] Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry

K Shirato, M Kawase, S Matsuyama - Virology, 2018 - Elsevier
Human coronaviruses (HCoVs) enter cells via two distinct pathways: the endosomal
pathway using cathepsins to activate spike protein and the cell-surface or early endosome …