Promoting equity in polygenic risk assessment through global collaboration

IJ Kullo - Nature Genetics, 2024 - nature.com
The long delay before genomic technologies become available in low-and middle-income
countries is a concern from both scientific and ethical standpoints. Polygenic risk scores …

Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

N Shrine, AG Izquierdo, J Chen, R Packer, RJ Hall… - Nature …, 2023 - nature.com
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …

A call to action to scale up research and clinical genomic data sharing

Z Stark, D Glazer, O Hofmann, A Rendon… - Nature Reviews …, 2024 - nature.com
Genomic data from millions of individuals have been generated worldwide to drive discovery
and clinical impact in precision medicine. Lowering the barriers to using these data …

Genomic architecture of autism spectrum disorder in Qatar: The BARAKA-Qatar Study

M Abdi, E Aliyev, B Trost, M Kohailan, W Aamer… - Genome Medicine, 2023 - Springer
Background Autism spectrum disorder (ASD) is a neurodevelopmental condition
characterized by impaired social and communication skills, restricted interests, and …

Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations

G Thareja, A Belkadi, M Arnold… - Human molecular …, 2023 - academic.oup.com
Polygenic scores (PGS) can identify individuals at risk of adverse health events and guide
genetics-based personalized medicine. However, it is not clear how well PGS translate …

[HTML][HTML] Out of the dark: the emerging roles of lncRNAs in pain

AM Habib, JJ Cox, AL Okorokov - Trends in Genetics, 2024 - cell.com
The dark genome, the nonprotein-coding part of the genome, is replete with long noncoding
RNAs (lncRNAs). These functionally versatile transcripts, with specific temporal and spatial …

Analysis of 14,392 whole genomes reveals 3.5% of Qataris carry medically actionable variants

A Elfatih, C Saad… - European Journal of …, 2024 - nature.com
Arabic populations are underrepresented in large genome projects; therefore, the frequency
of clinically actionable variants among Arabs is largely unknown. Here, we investigated …

Genetic predisposition to cancer across people of different ancestries in Qatar: a population-based, cohort study

M Saad, Y Mokrab, N Halabi, J Shan, R Razali… - The Lancet …, 2022 - thelancet.com
Background Disparities in the genetic risk of cancer among various ancestry groups and
populations remain poorly defined. This challenge is even more acute for Middle Eastern …

Mapping the Arab genome

H Mbarek, SI Ismail - Nature genetics, 2022 - nature.com
Mapping the Arab genome | Nature Genetics Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the …

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

J Shan, A Megarbane, A Chouchane, D Karthik… - Hepatology, 2023 - journals.lww.com
Abstract Background and Aims: Porto-sinusoidal vascular disorder (PSVD) is a group of liver
vascular diseases featuring lesions encompassing the portal venules and sinusoids …