Numerous key biological processes rely on the concept of multivalency, where ligands
achieve stable binding only upon engaging multiple receptors. These processes, like viral …

Sensors play a significant role in modern technologies and devices used in industries,
hospitals, healthcare, nanotechnology, astronomy, and meteorology. Sensors based upon …

Here, we show that the capacity to manufacture IL-2 identifies constituents of the expanded
CD8 T cell effector pool that display stem-like features, preferentially survive, rapidly attain …

Peripheral regulatory T (pTreg) cells are a key T cell lineage for mucosal immune tolerance
and anti-inflammatory responses, and interleukin-2 receptor (IL-2R) signaling is critical for …

Senescent cells produce a Senescence‐Associated Secretory Phenotype (SASP) that
involves factors with diverse and sometimes contradictory activities. One key SASP factor …

Engineered T cells represent an emerging therapeutic modality. However, complex
engineering strategies can present a challenge for enriching and expanding therapeutic …

Background Considering melanoma is the deadliest malignancy among dermatoma and
presently lacks effective therapies, there is an urgent need to investigate the potential …

Interleukin 2 (IL-2) is a key homeostatic cytokine, with therapeutic applications in both
immunogenic and tolerogenic immune modulation. Clinical use has been hampered by …

The interleukin-2 receptor (IL-2R) is a cytokine receptor essential for immunity that
transduces proliferative signals regulated by its uptake and degradation. IL-2R is a well …

Background Microwave ablation (MWA) is widely used to treat unresectable primary and
secondary malignancies of the liver, and a limited number of studies indicate that ablation …