Covalent attachment of myristate and/or palmitate occurs on a wide variety of viral and
cellular proteins. This review will highlight the latest advances in our understanding of the …

The Gag proteins of HIV-1, like those of other retroviruses, are necessary and sufficient for
the assembly of virus-like particles. The roles played by HIV-1 Gag proteins during the life …

During the late phase of HIV type 1 (HIV-1) replication, newly synthesized retroviral Gag
proteins are targeted to the plasma membrane of most hematopoietic cell types, where they …

HIV assembly and replication proceed through the formation of morphologically distinct
immature and mature viral capsids that are organized by the Gag polyprotein (immature) …

The human immunodeficiency virus type 1 initially assembles and buds as an immature
particle that is organized by the viral Gag polyprotein. Gag is then proteolyzed to produce …

The myristoylated matrix protein (myr-MA) of HIV functions as a regulator of intracellular
localization, targeting the Gag precursor polyprotein to lipid rafts in the plasma membrane …

Treatment of human cells with Type 1 interferons restricts HIV replication. Here we report
that the tripartite motif protein TRIM22 is a key mediator. We used transcriptional profiling to …

Myristoylation corresponds to the irreversible covalent linkage of the 14-carbon saturated
fatty acid, myristic acid, to the N-terminal glycine of many eukaryotic and viral proteins. It is …

HIV-1 Gag drives a number of events during the genesis of virions and is the only viral
protein required for the assembly of virus-like particles in vitro and in cells. Although a …

Retroviruses make a long and complex journey from outside the cell to the nucleus in the
early stages of infection, and then an equally long journey back out again in the late stages …