HLA class II polymorphism in Latin American patients with multiple sclerosis

OL Rojas, A Rojas-Villarraga, P Cruz-Tapias… - Autoimmunity …, 2010 - Elsevier
OBJECTIVE: To identify HLA-DRB1 alleles contributing to susceptibility to multiple sclerosis
(MS) in a Colombian population and to estimate the common effect size of HLA class II on …

PREDIVAC: CD4+ T-cell epitope prediction for vaccine design that covers 95% of HLA class II DR protein diversity

P Oyarzún, JJ Ellis, M Bodén, B Kobe - BMC bioinformatics, 2013 - Springer
Background CD4+ T-cell epitopes play a crucial role in eliciting vigorous protective immune
responses during peptide (epitope)-based vaccination. The prediction of these epitopes …

The role of HLA in MS susceptibility and phenotype

JM Greer - Emerging and Evolving Topics in Multiple Sclerosis …, 2015 - Springer
One of the most consistent findings in multiple sclerosis (MS) is that development of MS is
linked with carriage of the class II human leucocyte antigen (HLA) molecule HLA-DRB1* 15 …

[图书][B] Quantum biochemistry

CF Matta - 2010 - books.google.com
Divided into five major parts, the two volumes of this ready reference cover the tailoring of
theoretical methods for biochemical computations, as well as the many kinds of …

Structural and dynamical insights on HLA-DR2 complexes that confer susceptibility to multiple sclerosis in Sardinia: a molecular dynamics simulation study

A Kumar, E Cocco, L Atzori, MG Marrosu, E Pieroni - PloS one, 2013 - journals.plos.org
Sardinia is a major Island in the Mediterranean with a high incidence of multiple sclerosis, a
chronic autoimmune inflammatory disease of the central nervous system. Disease …

Interaction between HLA-DRB1-DQB1 haplotypes in Sardinian multiple sclerosis population

E Cocco, R Murru, G Costa, A Kumar, E Pieroni… - PLoS …, 2013 - journals.plos.org
We performed a case-control study in 2,555 multiple sclerosis (MS) Sardinian patients and
1,365 healthy ethnically matched controls, analyzing the interactions between HLA-DRB1 …

MHC 分子多态性的起源, 演变与抗病机理

陈芳芳, 潘玲, 耿照玉, 刘雪兰, 余为一 - 畜牧兽医学报, 2010 - xmsyxb.com
主要组织相容性复合体(Major histocompatibility complex, MHC) 的概念源于解释异体间组织
排斥和相容现象, 现已拓展为与抗感染以及所有免疫反应相关的基因群. MHC …

Genetic factors and multiple sclerosis in the Moroccan population: A role for HLA class II

S Ouadghiri, KEA Toussi, C Brick, EHA Benhaddou… - Pathologie …, 2013 - Elsevier
Background and objective Multiple sclerosis (MS) is an autoimmune inflammatory
demyelinating disease of the central nervous system that mainly affects young adults. The …

Methods in biocomputational chemistry: a lesson from the amino acids

HJ Bohórquez, C Cárdenas, CF Matta… - Quantum …, 2010 - Wiley Online Library
Computer-aided drug design (CADD) requires accurate and fast methods to identify and
characterize molecules with potential therapeutic use. While quantum mechanics (QM) …

Povezanost polimorfizma gena sustava HLA razreda I i II s oboljevanjem od multiple skleroze u sjeverozapadnoj Hrvatskoj

S Jagnjić - 2021 - repozitorij.pmf.unizg.hr
Sažetak Multipla skleroza (MS) je autoimuni poremećaj središnjeg živčanog sustava
uzrokovan međudjelovanjem genetičkih i okolišnih čimbenika rizika. Genetička …