Background RNA interference (RNAi), a newly developed method in which RNA molecules
inhibit gene expression, has recently received considerable research attention. In the …

RNA interference (RNAi), also known as gene silencing, is a biological process that
prevents gene expression in certain diseases such as cancer. It can be used to improve the …

Nanoparticles are rapidly being developed and trialed to overcome several limitations of
traditional drug delivery systems and are coming up as a distinct therapeutics for cancer …

Poly (ethylene imine) s (PEIs) are widely used in different applications, but most extensively
investigated as non-viral vector systems. The high ability of cationic PEIs to complex and …

Since the evolutionary discovery of RNA interference and its utilization for gene knockdown
in mammalian cell, a remarkable progress has been achieved in small interfering RNA …

Abstract siRNA is considered as a potent therapeutic agent because of its high specificity
and efficiency in suppressing genes that are overexpressed during disease development …

Small interfering RNA (siRNA) has been chemically conjugated to a variety of bioactive
molecules, lipids, polymers, peptides, and inorganic nanostructured materials to enhance …

Small interfering RNA (siRNA) is a relatively novel nucleic acid-based therapy to treat
diseases such as cancer. Nevertheless, substantial obstacles to its clinical applications have …

RNA interference (RNAi) is an evolutionarily conserved, endogenous process for post-
transcriptional regulation of gene expression. Although RNAi therapeutics have recently …

RNAi-based therapies are dependent on extracellular and intracellular delivery of RNA
molecules for enabling target interaction. Polycation-based nanoparticles (or polyplexes) …