Altered ER–mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models
KS Lee, S Huh, S Lee, Z Wu, AK Kim… - Proceedings of the …, 2018 - National Acad Sciences
Calcium (Ca2+) homeostasis is essential for neuronal function and survival. Altered Ca2+
homeostasis has been consistently observed in neurological diseases. How Ca2+ …
homeostasis has been consistently observed in neurological diseases. How Ca2+ …
Twin CHCH proteins, CHCHD2, and CHCHD10: key molecules of Parkinson's disease, amyotrophic lateral sclerosis, and frontotemporal dementia
Y Imai, H Meng, K Shiba-Fukushima… - International journal of …, 2019 - mdpi.com
Mutations of coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) and 10
(CHCHD10) have been found to be linked to Parkinson's disease (PD), amyotrophic lateral …
(CHCHD10) have been found to be linked to Parkinson's disease (PD), amyotrophic lateral …
Mitochondria Dysfunction in Frontotemporal Dementia/Amyotrophic Lateral Sclerosis: Lessons From Drosophila Models
S Anoar, NS Woodling, T Niccoli - Frontiers in Neuroscience, 2021 - frontiersin.org
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are
neurodegenerative disorders characterized by declining motor and cognitive functions. Even …
neurodegenerative disorders characterized by declining motor and cognitive functions. Even …
[HTML][HTML] Partial loss of MCU mitigates pathology in vivo across a diverse range of neurodegenerative disease models
MJ Twyning, R Tufi, TP Gleeson, KM Kolodziej… - Cell Reports, 2024 - cell.com
Summary Mitochondrial calcium (Ca 2+) uptake augments metabolic processes and buffers
cytosolic Ca 2+ levels; however, excessive mitochondrial Ca 2+ can cause cell death …
cytosolic Ca 2+ levels; however, excessive mitochondrial Ca 2+ can cause cell death …
Polo kinase phosphorylates miro to control ER-mitochondria contact sites and mitochondrial Ca2+ homeostasis in neural stem cell development
Mitochondria play central roles in buffering intracellular Ca 2+ transients. While basal
mitochondrial Ca 2+(Ca 2+ mito) is needed to maintain organellar physiology, Ca 2+ mito …
mitochondrial Ca 2+(Ca 2+ mito) is needed to maintain organellar physiology, Ca 2+ mito …
[HTML][HTML] Deregulation of ER-mitochondria contact formation and mitochondrial calcium homeostasis mediated by VDAC in fragile X syndrome
J Geng, TP Khaket, J Pan, W Li, Y Zhang, Y Ping… - Developmental cell, 2023 - cell.com
Loss of fragile X messenger ribonucleoprotein (FMRP) causes fragile X syndrome (FXS), the
most prevalent form of inherited intellectual disability. Here, we show that FMRP interacts …
most prevalent form of inherited intellectual disability. Here, we show that FMRP interacts …
PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation
T Comyn, T Preat, A Pavlowsky, PY Plaçais - Elife, 2024 - elifesciences.org
Relevance-based selectivity and high energy cost are two distinct features of long-term
memory (LTM) formation that warrant its default inhibition. Spaced repetition of learning is a …
memory (LTM) formation that warrant its default inhibition. Spaced repetition of learning is a …
Chchd2 regulates mitochondrial morphology by modulating the levels of Opa1
W Liu, X Duan, L Xu, W Shang, J Zhao… - Cell Death & …, 2020 - nature.com
The mitochondrion is a highly dynamic organelle that is critical for energy production and
numerous metabolic processes. Drosophila Chchd2, a homolog of the human disease …
numerous metabolic processes. Drosophila Chchd2, a homolog of the human disease …
p32 protein levels are integral to mitochondrial and endoplasmic reticulum morphology, cell metabolism and survival
MJ Hu, SA Crawford, DC Henstridge, IHW Ng… - Biochemical …, 2013 - portlandpress.com
p32 [also known as HABP1 (hyaluronan-binding protein 1), gC1qR (receptor for globular
head domains complement 1q) or C1qbp (complement 1q-binding protein)] has been shown …
head domains complement 1q) or C1qbp (complement 1q-binding protein)] has been shown …
Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Drosophila model of Parkinson's disease
Y Imai, T Inoshita, H Meng, K Shiba-Fukushima… - Communications …, 2019 - nature.com
Mitochondrial degeneration is considered one of the major causes of Parkinson's disease
(PD). Improved mitochondrial functions are expected to be a promising therapeutic strategy …
(PD). Improved mitochondrial functions are expected to be a promising therapeutic strategy …