Multi-omics research strategies in ischemic stroke: A multidimensional perspective

W Li, C Shao, H Zhou, H Du, H Chen, H Wan… - Ageing Research …, 2022 - Elsevier
Ischemic stroke (IS) is a multifactorial and heterogeneous neurological disorder with high
rate of death and long-term impairment. Despite years of studies, there are still no stroke …

Epigenetic mechanisms and potential therapeutic targets in stroke

KC Morris-Blanco, AK Chokkalla… - Journal of Cerebral …, 2022 - journals.sagepub.com
Accumulating evidence indicates a central role for epigenetic modifications in the
progression of stroke pathology. These epigenetic mechanisms are involved in complex and …

The mechanisms of long non-coding RNA-XIST in ischemic stroke: insights into functional roles and therapeutic potential

M Farzaneh, O Anbiyaee, S Azizidoost… - Molecular …, 2024 - Springer
Ischemic stroke, which occurs due to the occlusion of cerebral arteries, is a common type of
stroke. Recent research has highlighted the important role of long non-coding RNAs …

Unveiling the therapeutic potential of non-coding RNAs in stroke-induced tissue regeneration

A Waseem, AQ Khan, MA Khan, R Khan, S Uddin… - Stem Cells, 2023 - academic.oup.com
Stroke is a major contributor to mortality and impairment on a global scale, with few effective
treatments available. Aberrant expression of various non-coding RNAs (ncRNAs) has been …

LncRNA XIST exacerbates oxygen-glucose deprivation/reoxygenation-induced cerebral injury through the miR-25-3p/TRAF3 axis

Y Li, JK Zhang, ZT Yu, JW Jiang, H Tang, GL Tu… - Molecular …, 2023 - Springer
Ischemic stroke causes lethal damage to the brain. Identifying key regulators of OGD/R-
induced cerebral injury is important for developing novel therapies for ischemic stroke …

The emerging role of extracellular vesicle derived from neurons/neurogliocytes in central nervous system diseases: novel insights into ischemic stroke

F Li, X Kang, W Xin, X Li - Frontiers in Pharmacology, 2022 - frontiersin.org
Neurons and neurogliocytes (oligodendrocytes, astrocytes, and microglia) are essential for
maintaining homeostasis of the microenvironment in the central nervous system (CNS) …

Emerging role of LncRNAs in ischemic stroke—novel insights into the regulation of inflammation

Y Pan, Q Jiao, W Wei, T Zheng, X Yang… - Journal of Inflammation …, 2021 - Taylor & Francis
As a crucial kind of pervasive gene, long noncoding RNAs (lncRNAs) are abundant and key
players in brain function as well as numerous neurological disorders, especially ischemic …

The role of the lncRNA MALAT1 in neuroprotection against hypoxic/ischemic injury

L Wang, S Li, SS Stone, N Liu, K Gong, C Ren, K Sun… - Biomolecules, 2022 - mdpi.com
Hypoxic and ischemic brain injury can cause neurological disability and mortality, and has
become a serious public health problem worldwide. Long-chain non-coding RNAs are …

lncRNA H-19 and miR-200a implication and frequency of lncRNA H-19 rs2170425 SNP in ulcerative colitis and Crohn's disease

EH Khalil, OG Shaker, NA Hasona - Comparative Clinical Pathology, 2023 - Springer
Inflammation's impact on inflammatory bowel diseases is mostly due to altered non-coding
RNA expression. This study aimed to explore the rs2107425 polymorphism in the long non …

Non-coding RNAs in the regulation of blood–brain barrier functions in central nervous system disorders

P Sun, MH Hamblin, KJ Yin - Fluids and barriers of the CNS, 2022 - Springer
The blood–brain barrier (BBB) is an essential component of the neurovascular unit that
controls the exchanges of various biological substances between the blood and the brain …