Cochlear implants (CIs) provide acoustic information to implanted patients by electrically
stimulating nearby auditory nerve fibers (ANFs) which then transmit the information to higher …

Sensorineural hearing loss is caused by damage to sensory hair cells and/or spiral ganglion
neurons. In non-mammalian species, hair cell regeneration after damage is observed, even …

Objectives: Amplitudes of electrically evoked compound action potentials (eCAPs) as a
function of the stimulation level constitute the eCAP amplitude growth function (AGF). The …

Clinical application of the widely used chemotherapeutic agent, doxorubicin (DOX), is
limited by its cardiotoxicity. Mitochondrial dysfunction has been revealed as a crucial factor …

The electrically evoked compound action potential (eCAP) is a direct measure of the
responsiveness of the auditory nerve to electrical stimulation from a cochlear implant (CI) …

Neurotrophins promote neurite outgrowth of auditory neurons and may help closing the gap
to cochlear implant (CI) electrodes to enhance electrical hearing. The best concentrations …

Severe hearing loss or deafness is often caused by cochlear hair cell loss and can be
mitigated by a cochlear implant (CI). CIs target the auditory nerve, consisting of spiral …

We investigated whether treatment with brain-derived neurotrophic factor (BDNF), which is
known to protect spiral ganglion cells (SGCs), could also protect hair cells (HCs) and …

Neurotrophins (NTs) are pleiotropic molecules that can exert a variety of function in both the
central and peripheral nervous systems, modulating survival, development and function of …

Auditory neurons connect the sensory hair cells from the inner ear to the brainstem. These
bipolar neurons are relevant targets for pharmacological intervention aiming at protecting or …