Coronaviruses are pathogens with a serious impact on human and animal health. They
mostly cause enteric or respiratory disease, which can be severe and life threatening, eg, in …

Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …

Arteriviruses are positive-stranded RNA viruses that infect mammals. They can cause
persistent or asymptomatic infections, but also acute disease associated with a respiratory …

Coronaviruses infect a variety of mammalian and avian species and cause serious diseases
in humans, cats, mice, and birds in the form of severe acute respiratory syndrome (SARS) …

The well-known immunosuppressive drug cyclosporin A inhibits replication of various
viruses including coronaviruses by binding to cellular cyclophilins thus inactivating their cis …

Positive strand RNA viruses replicate in the cytoplasm of infected cells and induce
intracellular membranous compartments harboring the sites of viral RNA synthesis. These …

The coronavirus disease 2019 (COVID-19) pandemic is declared a global health
emergency. COVID-19 is triggered by a novel coronavirus: severe acute respiratory …

Until recently, there were no effective drugs available blocking coronavirus (CoV) infection in
humans and animals. We have shown before that CsA and FK506 inhibit coronavirus …

Cyclophilins (Cyps) belong to the family of peptidyl-prolyl isomerases (PPIases). The PPIase
activity of most Cyps is inhibited by the immunosuppressive drug cyclosporin A and several …

The present study sought to investigate whether porcine epidemic diarrhea virus (PEDV)
induces apoptosis and to elucidate the mechanisms associated with apoptotic cell death …