Computer-aided drug design techniques are today largely applied in medicinal chemistry. In
particular, receptor-based virtual screening (VS) studies, in which molecular docking …

The nicotinic acetylcholine receptor has served, since its biochemical identification in the
1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the …

Changeux et al.(Changeux et al. CR Biol. 343: 33–39.) recently suggested that the SARS-
CoV-2 spike protein may interact with nicotinic acetylcholine receptors (nAChRs) and that …

Changeux et al. recently suggested that the SARS-CoV-2 spike (S) protein may interact with
nicotinic acetylcholine receptors (nAChRs). Such interactions may be involved in pathology …

Bacterial biofilm is a major contributor to the persistence of infection and the limited efficacy
of antibiotics. Antibiofilm molecules that interfere with the biofilm lifestyle offer a valuable tool …

The α7 nicotinic acetylcholine receptor (nAChR) silent agonists, able to induce receptor
desensitization and promote the α7 metabotropic function, are emerging as new promising …

The inhibition of the PCSK9/LDLR protein-protein interaction (PPI) is a promising strategy for
developing new hypocholesterolemic agents. Recently, new antibodies have been …

During inflammatory reactions, the production and release of chemotactic factors guide the
recruitment of selective leukocyte subpopulations. The alarmin HMGB1 and the chemokine …

A set of racemic spirocyclic quinuclidinyl‐Δ2‐isoxazoline derivatives was synthesized using
a 1, 3‐dipolar cycloaddition‐based approach. Target compounds were assayed for binding …

Purpose The alpha7 nicotinic acetylcholine receptor (α7nAChR), involved in the modulation
of inflammation and insulin sensitivity, is downregulated in white adipose tissue (WAT) of …