Glioblastoma (GBM) is among the most deadly neoplasms associated with one of the worst
5-year overall survival (OS) rates among all human cancers. The aim of this systematic …

Thermosensitive hydrogels, having unique sol–gel transition properties, have recently
received special research attention. These hydrogels exhibit a phase transition near body …

Background Primary and adaptive resistance against chemo-and radiotherapy and local
recurrence after surgery limit the benefits from these standard treatments in glioma patients …

This article reviews recent developments in the application of cell-free DNA-based liquid
biopsies to neurological diseases. Over the past few decades, an explosion of interest in the …

Glioblastoma (GBM) is a particularly aggressive brain cancer associated with high
recurrence and poor prognosis. The standard of care, surgical resection followed by …

Sowing malignant cells (the “seeds” of metastasis) to engraft secondary sites requires a
conducive premetastatic niche (PMN, the “soil” of metastasis). Inflammation and tumor …

Gliomas are the most aggressive and lethal tumors of the central nervous system, for which
few therapeutic options exist. Surgical resection is the primary treatment for most gliomas; …

Early and progressive colonization of the healthy brain is one hallmark of diffuse gliomas,
including glioblastomas. We recently discovered ultralong (> 10 to hundreds of microns) …

Background Glioblastomas are highly resistant to therapy, and virtually all patients
experience tumor recurrence after standard-of-care treatment. Surgical tumor resection is a …

Background Glioblastoma (GBM) is the most common and aggressive primary brain tumor in
adults. Despite the gold standard treatment combining surgical resection, radiation and …