Nitric oxide: physiological functions, delivery, and biomedical applications

SM Andrabi, NS Sharma, A Karan… - Advanced …, 2023 - Wiley Online Library
Nitric oxide (NO) is a gaseous molecule that has a central role in signaling pathways
involved in numerous physiological processes (eg, vasodilation, neurotransmission …

The role of nitric oxide in tumour progression

D Fukumura, S Kashiwagi, RK Jain - Nature Reviews Cancer, 2006 - nature.com
Nitric oxide (NO) and nitric oxide synthases are ubiquitous in malignant tumours and are
known to exert both pro-and anti-tumour effects. We summarize our current understanding of …

The yin and yang of nitric oxide in cancer progression

AJ Burke, FJ Sullivan, FJ Giles, SA Glynn - Carcinogenesis, 2013 - academic.oup.com
Nitric oxide (NO) is a short-lived, pleiotropic molecule that affects numerous critical functions
in the body. Presently, there are markedly conflicting findings in the literature regarding NO …

Combating medical device fouling

JL Harding, MM Reynolds - Trends in biotechnology, 2014 - cell.com
When interfaced with the biological environment, biomedical devices are prone to surface
biofouling due to adhesion of microbial or thrombotic agents as a result of the foreign body …

Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1

LA Ridnour, JS Isenberg, MG Espey… - Proceedings of the …, 2005 - National Acad Sciences
Nitric oxide (NO) donors have been shown to stimulate and inhibit the proliferation,
migration, and differentiation of endothelial cells in vitro and angiogenesis in vivo. Recently …

Nitric oxide: role in tumour biology and iNOS/NO-based anticancer therapies

S Singh, AK Gupta - Cancer chemotherapy and pharmacology, 2011 - Springer
Purpose The diatomic radical nitric oxide (NO) has been the cause of intense debate with
implication in carcinogenesis, tumour progression, invasion, angiogenesis and modulation …

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

JS Isenberg, LA Ridnour… - Proceedings of the …, 2005 - National Acad Sciences
Redox signaling plays an important role in the positive regulation of angiogenesis by
vascular endothelial growth factor, but its role in signal transduction by angiogenesis …

The biphasic nature of nitric oxide responses in tumor biology

LA Ridnour, DD Thomas, S Donzelli… - Antioxidants & redox …, 2006 - liebertpub.com
The dual or biphasic responses of cancer to nitric oxide (NO) arise from its concentration
dependent ability to regulate tumor growth, migration, invasion, survival, angiogenesis, and …

Adaptation of skeletal muscle microvasculature to increased or decreased blood flow: role of shear stress, nitric oxide and vascular endothelial growth factor

O Hudlicka, MD Brown - Journal of vascular research, 2009 - karger.com
This review elucidates the roles of capillary haemodynamics, nitric oxide (NO) and vascular
endothelial growth factor (VEGF) in the remodelling of skeletal muscle microcirculation in …

CXCL13/CXCR5 axis facilitates endothelial progenitor cell homing and angiogenesis during rheumatoid arthritis progression

CH Tsai, CJ Chen, CL Gong, SC Liu, PC Chen… - Cell Death & …, 2021 - nature.com
Angiogenesis is a critical process in the formation of new capillaries and a key participant in
rheumatoid arthritis (RA) pathogenesis. The chemokine (CXC motif) ligand 13 (CXCL13) …