Abstract Ribonucleotide reductase M2 (RRM2) is a small subunit in ribonucleotide
reductases, which participate in nucleotide metabolism and catalyze the conversion of …

Epithelial-mesenchymal transition (EMT) as a trans-differentiation program and a key
process in tumor progression is linked positively with increased expansion of cancer stem …

Basal-like breast cancers (BLBCs) are among the most aggressive cancers, partly due to
their enrichment of cancer stem cells (CSCs). Breast CSCs can be generated from luminal …

TGFβ signaling and the DNA damage response (DDR) are two cellular toolboxes with a
strong impact on cancer biology. While TGFβ as a pleiotropic cytokine affects essentially all …

Basal-like breast cancer (BLBC) is highly aggressive, and often characterized by BRCA1
and p53 deficiency. Although conventional mouse models enabled the investigation of …

Abnormal expression of long non-coding RNAs (lncRNAs) plays an essential role in various
malignant neoplasia. As a newly identified lncRNA, LINC01234 is abnormally expressed in …

TAZ (WWTR1) is a transcriptional co-activator regulated by Hippo signaling, mechano-
transduction, and G-protein couple receptors. Once activated, TAZ and its paralogue, YAP1 …

Under different pathophysiological conditions, endothelial cells lose endothelial phenotype
and gain mesenchymal cell-like phenotype via a process known as endothelial-to …

Abstract Objective Downregulation of miR-17-5p has been reported in several cancers, but
whether and how miR-17-5p is downregulated in hepatocellular carcinoma (HCC) is …

Heterozygous mutations in any of three major genes, BRCA1, BRCA2 and PALB2, are
associated with high-risk hereditary breast cancer susceptibility frequently seen as familial …