Simple Summary Glioblastoma multiforme is a brain tumor with a very unfavorable
prognosis, where the vast majority of patients do not survive a year after diagnosis. One line …

Background: Humans are exposed to mixtures of toxicants that can impact several biological
pathways. We investigated the associations between multiple classes of toxicants and an …

Epoxyeicosatrienoic acids (EETs) are formed from the metabolism of arachidonic acid by
cytochrome P450s. EETs promote angiogenesis linked to tumor growth in various cancer …

The first total synthesis of a docosahexaenoic acid (DHA)-like methoxylated ether lipid
(MEL) is reported. This compound constitutes an all-cis methylene skipped hexaene …

A concise and stereoselective synthesis of a key fragment C3-C22 unit of tartrolons D and E
is demonstrated. Three crucial fragments are combined to form the 20-carbon chain, which …

Oxidative stress (OS) is a physiological mechanism that is induced by pollutants and can
lead to pathophysiological conditions. Pollutants may be activated by phase I metabolism …

Pulmonary arterial hypertension (PAH) is a fatal vascular disease within the lungs
characterized by oxidative stress and endothelial cell proliferation. Associated with this …

Chiral amines are present in a vast number of pharmaceutical compounds, biologically
active natural products, and throughout nature. While the synthesis of chiral amines …

Introduction: Atherosclerosis is an inflammatory disease of the arteries that underlies several
cardiovascular diseases (CVD). CVD are the leading cause of death and disability …

It has previously been reported that arachidonic acid (ARA) derivatives, epoxyeicosatrienoic
acids (EETs), enhance axonal growth in rat sensory and cortical neuronal cell cultures. The …