Pertussis is a severe respiratory infection caused by Bordetella pertussis, and in 2008,
pertussis was associated with an estimated 16 million cases and 195,000 deaths globally …

Adult bone marrow derived mesenchymal stem cells offer the potential to open a new
frontier in medicine. Regenerative medicine aims to replace effete cells in a broad range of …

Chemokines play well established roles as attractants of naïve and effector T cells. New
studies indicate that chemokines also have roles in regulating T cell differentiation. Blocking …

Bordetella pertussis causes whooping cough, a severe respiratory tract infection in infants
and children, and also infects adults. Studies in murine models have shown that innate …

Publisher Summary Although interleukin-12 (IL-12) has been discovered only relatively
recently, a remarkable level of knowledge has been obtained for this cytokine, and many …

Whole cell pertussis vaccines (Pw) induce Th1 responses and protect against Bordetella
pertussis infection, whereas pertussis acellular vaccines (Pa) induce Ab and Th2-biased …

The results of phase 3 efficacy trials have shown that acellular and whole-cell pertussis
vaccines can confer protection against whooping cough. However, despite the advances in …

Bordetella pertussis exploits extracellular and intracellular niches in the respiratory tract and
a variety of immune evasion strategies to prolong its survival in the host. This article reviews …

Recent clinical trials have demonstrated that new generation acellular pertussis vaccines
can confer protection against whooping cough. However, the mechanism of protective …

Interleukin-12 (IL-12) is a potent immunoregulatory cytokine that is crucially involved in a
wide range of infectious diseases. In several experimental models of bacterial, parasitic …