The integrated stress response (ISR) is a highly conserved biochemical pathway involved in
maintaining proteostasis and cell health in the face of diverse stressors. In this Review, we …

Parkinson's disease (PD) is a neurodegenerative disease that primarily affects elderly
people. The mechanism on onset and progression of PD is unknown. Currently, there are no …

Impairment of oligodendrocytes and myelin contributes to neurological disorders including
multiple sclerosis (MS), stroke, and Alzheimer's disease. Regeneration of myelin …

Background Some paroxysmal movement disorders remain without an identified genetic
cause. Objectives The aim was to identify the causal genetic variant for a paroxysmal …

Background Dystonia in cerebral palsy (CP) is classically associated with deep gray matter
injury at term gestation, but the patterns of injury associated with dystonia following …

Parkinson's disease (PD) is a prevalent neurodegenerative disease, characterized by
movement disorders and non-motor symptoms like cognitive impairment and depression …

Myelin is an electrical insulator that enables saltatory nerve conduction and is essential for
proper functioning of the central nervous system (CNS). It is formed by oligodendrocytes …

Background and Objectives Adult-onset idiopathic focal cervical dystonia (AOIFCD) involves
abnormal posturing of the cervical musculature and, in some individuals, an associated …

Advances in sequencing technologies have identified novel genes associated with inherited
forms of dystonia, providing valuable insights into its genetic basis and revealing diverse …

Abstract Background and Objectives Adult-onset idiopathic focal cervical dystonia (AOIFCD)
involves loss of co-ordinated contraction of the cervical musculature, resulting in pain …