Frontotemporal pathology in motor neuron disease phenotypes: Insights from neuroimaging

MC McKenna, P Corcia, P Couratier, WF Siah… - Frontiers in …, 2021 - frontiersin.org
Frontotemporal involvement has been extensively investigated in amyotrophic lateral
sclerosis (ALS) but remains relatively poorly characterized in other motor neuron disease …

[HTML][HTML] Cognitive dysfunction in amyotrophic lateral sclerosis: can we predict it?

F De Marchi, C Carrarini, A De Martino, L Diamanti… - Neurological …, 2021 - Springer
Conclusions To date, the research on humoral, radiological, neurophysiological, and
genetic correlates of neuropsychological alterations is at the early stage, and no conclusive …

Amyotrophic lateral sclerosis–frontotemporal dementia: Shared and divergent neural correlates across the clinical spectrum

C Cividini, S Basaia, EG Spinelli, E Canu… - Neurology, 2022 - AAN Enterprises
Background and Objectives A significant overlap between amyotrophic lateral sclerosis
(ALS) and behavioral variant of frontotemporal dementia (bvFTD) has been observed at …

Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults

E Rodriguez-Vieitez, V Montal, J Sepulcre, C Lois… - Molecular …, 2021 - nature.com
Noninvasive biomarkers of early neuronal injury may help identify cognitively normal
individuals at risk of developing Alzheimer's disease (AD). A recent diffusion-weighted …

Regional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients

E Solana, E Martinez-Heras, V Montal, E Vilaplana… - Scientific reports, 2021 - nature.com
The spatio-temporal characteristics of grey matter (GM) impairment in multiple sclerosis (MS)
are poorly understood. We used a new surface-based diffusion MRI processing tool to …

Feature selection from magnetic resonance imaging data in ALS: a systematic review

TD Kocar, HP Mueller, AC Ludolph… - … advances in chronic …, 2021 - journals.sagepub.com
Background: With the advances in neuroimaging in amyotrophic lateral sclerosis (ALS), it
has been speculated that multiparametric magnetic resonance imaging (MRI) is capable to …

Severity of in vivo corticospinal tract degeneration is associated with survival in amyotrophic lateral sclerosis: a longitudinal, multicohort study

D Ta, AH Ishaque, A Elamy, T Anand… - European Journal of …, 2023 - Wiley Online Library
Background and purpose This study sought to evaluate the relationship of progressive
corticospinal tract (CST) degeneration with survival in patients with amyotrophic lateral …

Association of cortical and subcortical microstructure with disease severity: impact on cognitive decline and language impairments in frontotemporal lobar …

W Ding, P Ren, L Yi, Y Si, F Yang, Z Li, H Bao… - Alzheimer's Research & …, 2023 - Springer
Background Cortical and subcortical microstructural modifications are critical to
understanding the pathogenic changes in frontotemporal lobar degeneration (FTLD) …

Cortical microstructure in primary progressive aphasia: a multicenter study

I Illán-Gala, V Montal, S Borrego-Écija… - Alzheimer's Research & …, 2022 - Springer
Background Cortical mean diffusivity is a novel imaging metric sensitive to early changes in
neurodegenerative syndromes. Higher cortical mean diffusivity values reflect microstructural …

Pathophysiological underpinnings of extra-motor neurodegeneration in amyotrophic lateral sclerosis: new insights from biomarker studies

D Reyes-Leiva, O Dols-Icardo, S Sirisi… - Frontiers in …, 2022 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) lie at
opposing ends of a clinical, genetic, and neuropathological continuum. In the last decade, it …