JCJ Eikenboom - Best practice & research Clinical haematology, 2001 - Elsevier
von Willebrand disease type 3 is the most severe form of this condition. Patients present with a moderate-to-severe bleeding tendency. The plasma von Willebrand factor level in these …
A Goodeve, J Eikenboom, G Castaman, F Rodeghiero… - Blood, 2007 - ashpublications.org
Type 1 von Willebrand disease (VWD) is characterized by a personal and family history of bleeding coincident with reduced levels of normal plasma von Willebrand factor (VWF). The …
AB Federici, P Bucciarelli, G Castaman… - Blood, The Journal …, 2014 - ashpublications.org
Analyses of the bleeding tendency by means of the bleeding score (BS) have been proposed until now to confirm diagnosis but not to predict clinical outcomes in patients with …
M Lak, F Peyvandi, PM Mannucci - British journal of …, 2000 - Wiley Online Library
Type 3 is the most severe form of von Willebrand disease (VWD) transmitted as an autosomal recessive trait. We collected data on the clinical manifestations of type 3 VWD by …
PM Mannucci, C Kempton, C Millar… - Blood, The Journal …, 2013 - ashpublications.org
Safety and pharmacokinetics (PK) of recombinant von Willebrand factor (rVWF) combined at a fixed ratio with recombinant factor VIII (rFVIII) were investigated in 32 subjects with type 3 …
AB Federici, G Castaman, PM Mannucci… - …, 2002 - Wiley Online Library
von Willebrand disease (vWD) is a bleeding disorder caused by quantitative (type 1 and 3) or qualitative (type 2) defects of von Willebrand factor (vWF). The molecular basis of type …
L Baronciani, G Cozzi, MT Canciani, F Peyvandi… - Blood Cells, Molecules …, 2003 - Elsevier
Type 3 von Willebrand disease (VWD) is characterized by unmeasurable von Willebrand factor (VWF) levels in plasma and platelets and severe hemorrhagic symptoms. We have …
L Baronciani, I Peake, R Schneppenheim… - Blood …, 2021 - ashpublications.org
Type 3 von Willebrand disease (VWD3) is a rare and severe bleeding disorder characterized by often undetectable von Willebrand factor (VWF) plasma levels, a recessive …
O Seidizadeh, L Baronciani, MT Pagliari… - Journal of Thrombosis …, 2023 - Elsevier
Abstract Background Enhanced von Willebrand factor (VWF) clearance from plasma is associated with von Willebrand disease (VWD). However, the genetic background of this …