BACKGROUND: Von Willebrand's disease (VWD) is an autosomally inherited bleeding
disorder caused by a deficiency or abnormality of von Willebrand factor (VWF). VWF is a …

von Willebrand disease type 3 is the most severe form of this condition. Patients present with
a moderate-to-severe bleeding tendency. The plasma von Willebrand factor level in these …

Type 1 von Willebrand disease (VWD) is characterized by a personal and family history of
bleeding coincident with reduced levels of normal plasma von Willebrand factor (VWF). The …

Analyses of the bleeding tendency by means of the bleeding score (BS) have been
proposed until now to confirm diagnosis but not to predict clinical outcomes in patients with …

Type 3 is the most severe form of von Willebrand disease (VWD) transmitted as an
autosomal recessive trait. We collected data on the clinical manifestations of type 3 VWD by …

Safety and pharmacokinetics (PK) of recombinant von Willebrand factor (rVWF) combined at
a fixed ratio with recombinant factor VIII (rFVIII) were investigated in 32 subjects with type 3 …

von Willebrand disease (vWD) is a bleeding disorder caused by quantitative (type 1 and 3)
or qualitative (type 2) defects of von Willebrand factor (vWF). The molecular basis of type …

Type 3 von Willebrand disease (VWD) is characterized by unmeasurable von Willebrand
factor (VWF) levels in plasma and platelets and severe hemorrhagic symptoms. We have …

Type 3 von Willebrand disease (VWD3) is a rare and severe bleeding disorder
characterized by often undetectable von Willebrand factor (VWF) plasma levels, a recessive …

Abstract Background Enhanced von Willebrand factor (VWF) clearance from plasma is
associated with von Willebrand disease (VWD). However, the genetic background of this …