Neuronal primary cilia have recently emerged as important contributors to the central
regulation of energy homeostasis. As non-motile, microtubule-based organelles, primary …

The TMEM16A/anoctamin-1 calcium-activated chloride channel (CaCC) contributes to a
range of vital functions, such as the control of vascular tone and epithelial ion transport. The …

Cilia and flagella play important roles in cell motility and cell signaling. These functions
require that the cilium establishes and maintains a unique lipid and protein composition …

In many sensory organs, specialized receptors are strategically arranged to enhance
detection sensitivity and acuity. It is unclear whether the olfactory system utilizes a similar …

Cilia are microtubule-based organelles and perform motile, sensing and signaling functions.
The assembly and maintenance of cilia depend on intraflagellar transport (IFT). Besides …

Obesity and major depressive disorder (MDD) are both significant health issues that have
been increasing in prevalence and are associated with multiple comorbidities. Obesity and …

The primary cilium is a solitary, microtubule-based membrane protrusion extending from the
surface of quiescent cells that senses the cellular environment and triggers specific cellular …

The guanine nucleotide protein (G protein)-coupled receptors (GPCRs) superfamily
represents the largest class of membrane protein in the human genome. More than a half of …

The primary cilia of forebrain neurons assemble around birth and become enriched with
neuromodulatory receptors. Our understanding of the permanence of these structures and …

In the last decade highly conserved cellular appendages called cilia have enjoyed a
renewed interest from basic, biomedical scientists, and clinicians alike. This interest has …