[HTML][HTML] Treatment-resistant OCD: Pharmacotherapies in adults

PJ Van Roessel, G Grassi, EN Aboujaoude… - Comprehensive …, 2023 - Elsevier
Serotonin reuptake inhibitor (SRI) medications are well established as first-line
pharmacotherapeutic treatment for Obsessive-Compulsive Disorder (OCD). However …

Psychotherapy with psilocybin for depression: systematic review

JJ Dawood Hristova, V Pérez-Jover - Behavioral Sciences, 2023 - mdpi.com
Depression is a common mental health issue that affects 280 million people in the world with
a high mortality rate, as well as being a leading cause of disability. Psychopharmacological …

Striking long-term beneficial effects of single dose psilocybin and psychedelic mushroom extract in the SAPAP3 rodent model of OCD-like excessive self-grooming

M Brownstien, M Lazar, A Botvinnik, C Shevakh… - Molecular …, 2024 - nature.com
Obsessive compulsive disorder (OCD) is a highly prevalent disorder that causes serious
disability. Available treatments leave 40% or more of people with OCD significantly …

A journey with psychedelic mushrooms: From historical relevance to biology, cultivation, medicinal uses, biotechnology, and beyond

M Pepe, M Hesami, KA de la Cerda, ML Perreault… - Biotechnology …, 2023 - Elsevier
Psychedelic mushrooms containing psilocybin and related tryptamines have long been used
for ethnomycological purposes, but emerging evidence points to the potential therapeutic …

Improvement in OCD symptoms associated with serotoninergic psychedelics: a retrospective online survey

A Buot, C Pallares, A Oganesyan, C Dauré… - Scientific Reports, 2023 - nature.com
A renewed interest in the use of psychedelics for treating obsessive compulsive disorder
(OCD) has emerged in the last 20 years. But pre-clinical and clinical evidence remain …

Therapeutic uses of psychedelics for eating disorders and body dysmorphic disorder

N Ledwos, JD Rodas, MI Husain… - Journal of …, 2023 - journals.sagepub.com
Background: Clinical use of psychedelics has gained considerable attention, with promising
benefits across a range of mental disorders. Current pharmacological and …

Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder

S Singh, A Botvinnik, O Shahar, G Wolf… - Translational …, 2023 - nature.com
Preliminary clinical findings, supported by preclinical studies employing behavioral
paradigms such as marble burying, suggest that psilocybin may be effective in treating …

Single-dose psilocybin for treatment-resistant obsessive-compulsive disorder: a case report

B Kelmendi, SA Kichuk, G DePalmer, G Maloney… - Heliyon, 2022 - cell.com
Classic psychedelics, such as psilocybin, act on the brain's serotonin system and produce
striking psychological effects. Early work in the 1950s and 1960s and more recent controlled …

Reduced death anxiety and obsessive beliefs as mediators of the therapeutic effects of psychedelics on obsessive compulsive disorder symptomology

SG Moreton, A Burden-Hill, RE Menzies - Clinical Psychologist, 2023 - Taylor & Francis
Objective Emerging research suggests that the use of serotonergic psychedelics can be
associated with reductions in obsessions and compulsions. However, little research to date …

Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus …

KF Kiilerich, J Lorenz, MB Scharff, N Speth… - Molecular …, 2023 - nature.com
Psilocybin (a classic serotonergic psychedelic drug) has received appraisal for use in
psychedelic-assisted therapy of several psychiatric disorders. A less explored topic …